血液C-反应蛋白水平与抑郁症关系的系统评价

发布时间：2018-06-06 23:40

本文选题：抑郁症 + C-反应蛋白　；参考：《重庆医科大学学报》2015年01期

【摘要】：目的:探讨社区和临床人群中血液C-反应蛋白(C-reactive protein,CRP)水平与抑郁症的关系。方法:使用Cochrane Library、Pub Med、Web of knowledge、Ebsco、中国生物医学文献数据库、中国学术期刊全文数据库、万方数据库以及维普中文科技期刊全文数据库,检索和筛选抑郁症CRP水平的病例对照研究,检索日期至2013年10月。对纳入文献进行质量评价和数据提取后,用Review manager 5.0软件进行Meta分析。结果:Meta分析纳入文献共13篇,其中抑郁患者2 779例,正常对照人群6 189例。结果显示男性、女性及总抑郁人群血液CRP均高于正常对照人群,结果具有统计学差异:总人群WMD=0.32(95%CI=0.13~0.51,P=0.000);男性人群WMD=0.33(95%CI=-0.02~0.69,P=0.070);女性人群WMD=0.29(95%CI=0.06~0.52,P=0.020)。结论:抑郁症患者血液CRP水平明显增高,对抑郁症的早期发现和准确诊断具有重要的指导意义。
[Abstract]:Objective: to investigate the relationship between serum C-reactive protein (CRP) level and depression in community and clinical population. Methods: using Cochrane Library of knowledge, Chinese biomedical literature database, Chinese academic journal full-text database, Wanfang database and Weipu Chinese sci-tech journal full-text database, a case-control study was conducted to search and screen the CRP level of depression. The search date is up to October 2013. After quality evaluation and data extraction, Meta analysis was carried out with Review manager 5.0 software. Results 13 articles were included in the analysis, including 2 779 depressive patients and 6 189 normal controls. The results showed that the blood CRP of male, female and total depressed group were higher than that of normal control group. The results were as follows: WMD0.32 ~ 95%, WMD0.130.51 ~ 0.51 ~ 0.000, WMD0.3395% CI-0.02 ~ -0.69 ~ (9) P0. 070, and female WMD0.2995CII 0.060.52 ~ 0. 020 ~ 0. 020. Conclusion: the level of CRP in patients with depression is significantly higher, which is of great significance for early detection and accurate diagnosis of depression.
【作者单位】：重庆医科大学神经科学研究中心;
【基金】：国家重大科学研究(973)计划资助项目(编号:2009CB918302)
【分类号】：R749.4

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