运用fMRI对抑郁症及一级亲属的静息态脑功能分析研究

发布时间：2018-06-13 19:54

本文选题：抑郁症 + 磁共振成像　；参考：《中国临床医学影像杂志》2017年10期

【摘要】：目的:探讨抑郁症及一级亲属静息状态下脑区的局部一致性(ReHo)的特点及差异,以了解抑郁症患者的脑功能状态。方法:前瞻性研究15例抑郁症患者(抑郁症组)、15例抑郁症一级亲属(一级亲属组)、15名健康志愿者(对照组),分别进行3.0T静息态脑功能磁共振(fMRI)成像。结果 :与一级亲属组相比,抑郁症组的右侧额中回、右侧中央前回、右侧额上回、右侧前扣带回、右侧脑岛、左侧壳核、左侧颞上回、左侧颞中回、左侧背侧扣带回的ReHo值显著性降低(P0.05);与对照组相比,抑郁症组的左侧中央后回、左侧颞上回、左侧颞中回、左侧额下回、左侧眶额叶皮质、左侧背侧扣带回、右侧中央前回、右侧内侧前额叶皮质、右侧额上回、双侧额中回、双侧前扣带回、右侧脑岛的ReHo值显著减低(P0.05);与对照组相比,一级亲属组的左侧小脑前叶、左侧颞上回、左侧额下回、左侧眶额叶皮质、左侧额上回、左侧背侧扣带回、左侧脑岛、右侧额中回、右侧前扣带回的ReHo值显著降低(P0.05)。结论 :抑郁症患者及一级亲属脑区均存在广泛的ReHo异常,这些异常的脑区可能与抑郁症认知网络障碍及情感低落相关。
[Abstract]:Objective: to investigate the characteristics and differences of local consistency of brain regions in depression and first-degree relatives in order to understand the state of brain function in patients with depression. Methods: a prospective study of 15 patients with depression (depression group, 15 patients with depression first degree relatives (first degree relatives group) 15 healthy volunteers (control group, 3. 0T resting brain functional magnetic resonance imaging) were performed. Results: the right middle frontal gyrus, right precentral gyrus, right superior frontal gyrus, right anterior cingulate gyrus, right cerebral island, left putamen nucleus, left superior temporal gyrus, left middle temporal gyrus, left superior temporal gyrus, right superior frontal gyrus, right anterior cingulate gyrus, right Compared with the control group, the left posterior central gyrus, left superior temporal gyrus, left middle temporal gyrus, left inferior frontal gyrus, left orbital frontal cortex, left dorsal cingulate gyrus and right precentral gyrus were significantly decreased in left dorsal cingulate gyrus. In the right medial prefrontal cortex, right superior frontal gyrus, bilateral middle frontal gyrus, bilateral anterior cingulate gyrus, the ReHo value of the right cerebral island decreased significantly (P 0.05), compared with the control group, the left cerebellum anterior lobe, left superior temporal gyrus, left inferior frontal gyrus in the first degree relatives group, The value of ReHo in left orbital frontal cortex, left superior frontal gyrus, left dorsal cingulate gyrus, left islet, right middle frontal gyrus and right anterior cingulate gyrus decreased significantly (P 0.05). Conclusion: there are extensive ReHo abnormalities in depressive patients and first-degree relatives. These abnormal brain regions may be related to depression cognitive network disorder and depression.
【作者单位】：滨州医学院烟台附属医院影像科;滨州医学院附属医院影像科;烟台毓璜顶医院;
【基金】：山东省自然科学基金(编号ZR2016HL40)
【分类号】：R445.2;R749.4

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