海洛因依赖患者大脑灰质异常研究

发布时间：2018-06-18 15:35

本文选题：药物依赖 + 海洛因成瘾　；参考：《西安电子科技大学》2012年硕士论文

【摘要】：海洛因成瘾作为一种慢性脑疾病，影响大脑一系列回路，例如：控制回路、记忆回路、奖赏回路、动机回路。之前的影像学研究已经揭示出海洛因成瘾患者与正常人的大脑结构和功能上的异常，这些研究发现大大地提高了我们对海洛因成瘾机制的理解。目前针对大脑灰质结构差异的研究主要采用基于体素的形态学分析方法，该方法考察的是大脑灰质体积，然而目前海洛因依赖对大脑皮层厚度的影响尚不明确。首先，本文详细的阐述了基于体素的形态学测量方法和皮层厚度测量方法的基本原理。其次，本研究纳入了11个海洛因依赖患者和13个年龄、性别、教育程度相匹配的正常对照，为了能够更好的解释皮层厚度测量结果，本文利用以上被试的影像学数据，采用基于体素的形态学分析方法进行大脑灰质体积变化的研究。最后，我们在这同一批数据的基础上，使用Freesurfer软件进行皮层厚度差异的研究，并将所得结果与灰质体积差异研究所得结果进行对比分析。这一结果也在一定程度上支持了皮层灰质体积是大脑皮层形态学变化的一种混合测量效果，，而皮层厚度仅是一个单一属性的事实。基于体素的形态学分析和皮层厚度测量均表明，海洛因成瘾患者大脑灰质显著萎缩的区域有：左侧大脑的额中回上部、双侧额中回下部、右侧额上回、双侧框额部皮质外侧、左侧扣带回峡部、双侧颞下回、左侧颞中回、和双侧脑岛。实验结果证明，在今后的研究中，将基于体素的形态学分析方法和皮层厚度测量技术进行联合分析可以更加全面的描述脑结构的形态学变化。本研究属于应用数学与生物医学的跨学科交叉研究。
[Abstract]:Heroin addiction, as a chronic brain disease, affects a series of brain circuits, such as control, memory, reward and motivation. Previous imaging studies have revealed structural and functional abnormalities in the brain of heroin addicts and normal people, and these findings have significantly improved our understanding of the mechanism of heroin addiction. At present, the morphological analysis method based on voxel is mainly used to study the difference of gray matter structure in the brain. The volume of gray matter is measured by this method. However, the effect of heroin dependence on the thickness of cerebral cortex is still unclear. Firstly, the basic principles of morphology measurement and cortical thickness measurement based on voxel are described in detail. Secondly, this study included 11 heroin addicts and 13 normal controls matched with age, sex and education. In order to better explain the cortical thickness measurement results, we used the imaging data of the above subjects. The volume changes of gray matter in brain were studied by morphologic analysis based on voxel. Finally, on the basis of the same data, we use Freesurfer software to study the cortical thickness difference, and compare the results with the results of gray matter volume difference research. The results also support to some extent that the volume of cortical gray matter is a mixed measurement effect of morphological changes of cerebral cortex, while the thickness of cortex is only a single attribute. Morphologic analysis and cortical thickness measurement based on voxel showed that the areas with significant atrophy of gray matter in heroin addicts included the upper middle frontal gyrus, the lower middle frontal gyrus, the right superior frontal gyrus, the lateral frontal cortex of the bilateral frame, the middle frontal gyrus on the left side, and the middle frontal gyrus on both sides. Left cingulate gyrus isthmus, bilateral inferior temporal gyrus, left middle temporal gyrus, and bilateral cerebral island. The experimental results show that the combined analysis of morphologic analysis based on voxel and measurement of cortical thickness can more comprehensively describe the morphological changes of brain structure in the future. This study is a cross-disciplinary study of applied mathematics and biomedicine.
【学位授予单位】：西安电子科技大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749.6

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