丁螺环酮联合帕罗西汀治疗老年抑郁症伴焦虑症状的临床观察

发布时间：2018-07-05 13:30

本文选题：丁螺环酮 + 帕罗西汀　；参考：《中国药房》2016年21期

【摘要】：目的:观察丁螺环酮联合帕罗西汀治疗老年抑郁症伴焦虑症状的疗效和安全性。方法:78例老年抑郁症伴焦虑症状患者随机分为对照组(39例)和观察组(39例)。对照组患者给予盐酸帕罗西汀片20~40 mg,每日早餐后半小时内顿服;观察组患者在对照组治疗的基础上给予盐酸丁螺环酮片5~10 mg,口服,每日3次。两组疗程均为8周。观察两组患者的临床疗效,治疗前及治疗2、4、8周后的汉密尔顿抑郁量表(HAMD)评分、汉密尔顿焦虑量表(HAMA)评分及治疗过程中的副反应量表(TESS)评分。结果:观察组患者总有效率显著高于对照组,差异有统计学意义(P0.05)。对照组患者治疗4、8周后HAMD评分及治疗8周后HAMA评分,观察组患者治疗2、4、8周后HAMD评分及HAMA评分均显著低于同组治疗前,随治疗时间延长逐渐降低,且观察组低于对照组,差异均有统计学意义(P0.05或P0.01)。治疗过程中,两组患者TESS评分比较,差异均无统计学意义(P0.05)。结论:丁螺环酮联合帕罗西汀治疗老年抑郁症伴焦虑症状的疗效优于单用帕罗西汀,且安全性较好。
[Abstract]:Objective: to observe the efficacy and safety of buspirone combined with paroxetine in the treatment of senile depression with anxiety symptoms. Methods Seventy-eight elderly depression patients with anxiety symptoms were randomly divided into control group (39 cases) and observation group (39 cases). The patients in the control group were given paroxetine hydrochloride 2040 mg daily for half an hour after breakfast, while the patients in the observation group were given 10 mg buspirone hydrochloride tablets on the basis of the treatment in the control group, three times a day. The course of treatment was 8 weeks in both groups. The clinical efficacy, Hamilton depression scale (Hamd), Hamilton anxiety scale (Hama) and side effects scale (Tess) were measured before and 8 weeks after treatment. Results: the total effective rate of the observation group was significantly higher than that of the control group, the difference was statistically significant (P0.05). The Hamd score and Hama score of the control group were significantly lower than those of the control group after 8 weeks of treatment and the Hama scores of the observation group were significantly lower than those of the control group after 8 weeks of treatment, and decreased gradually with the prolongation of the treatment time, and those of the observation group were lower than those of the control group. The difference was statistically significant (P0.05 or P0.01). In the course of treatment, there was no significant difference in Tess score between the two groups (P0.05). Conclusion: the efficacy of buspirone combined with paroxetine in the treatment of senile depression with anxiety symptoms is better than that of paroxetine alone.
【作者单位】：自贡市第五人民医院;
【分类号】：R749.4;R749.72

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