首发儿童青少年精神分裂症脑磁共振弥散张量成像研究
发布时间：2018-07-28 09:48
【摘要】：目的应用弥散张量成像(DTI)技术获取全脑白质各向异性(FA)值,研究首发儿童青少年精神分裂症全脑白质纤维是否受到损害,探讨早发精神分裂症的白质异常与精神分裂症的关联性。方法入组符合DSM-Ⅳ诊断标准的首发精神分裂症患者共19例(患者组),患者年龄均小于18岁,没有使用过任何抗精神病药物。同时选取19名年龄、性别相匹配的健康自愿者(对照组)。所有的患者和健康对照者都接受了DTI和结构相的磁共振成像(MRI)扫描。检测大脑各区域的FA值,分析患者组与健康对照组之间FA值的差异。结果患者组左额下回、左颞下回、左枕叶、右颞中回白质FA值显著低于健康对照组(P0.001)。结论首发儿童青少年精神分裂症患者脑区存在广泛的白质损伤,提示白质异常可能与早发精神分裂的发病相关。
[Abstract]:Objective to obtain the anisotropic (FA) values of the white matter of the whole brain by using diffusion Zhang Liang imaging (DTI), and to study whether the white matter fibers of the whole brain were damaged in the first episode of schizophrenia in children and adolescents. To investigate the relationship between white matter abnormality and schizophrenia in early onset schizophrenia. Methods A total of 19 first-episode schizophrenia patients (patients group) who met the diagnostic criteria of DSM- 鈪，
本文编号：2149701
[Abstract]:Objective to obtain the anisotropic (FA) values of the white matter of the whole brain by using diffusion Zhang Liang imaging (DTI), and to study whether the white matter fibers of the whole brain were damaged in the first episode of schizophrenia in children and adolescents. To investigate the relationship between white matter abnormality and schizophrenia in early onset schizophrenia. Methods A total of 19 first-episode schizophrenia patients (patients group) who met the diagnostic criteria of DSM- 鈪，
本文编号：2149701
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