抑郁症情绪记忆性别差异fMRI研究
发布时间:2018-07-28 11:42
【摘要】:研究背景及目的抑郁症(MDD)是一种情感性精神障碍性疾病,临床以心境低落为主要特征的精神疾病综合症。抑郁症发病率及患病率存在性别差异,男女之比约为1:2。抑郁症性别差异的认知神经机制已成为国内外神经学和脑科学研究热点之一。正常人性别差异的脑区结构和功能已被诸多研究证实,用功能磁共振研究发现情绪记忆相关的杏仁核激活存在性别差异,这种性别差异与抑郁症患者性别差异是否存在关联,有待进一步研究。目前国内外有少数关于抑郁症患者脑结构和静息态功能磁共振成像性别差异的研究报导,但很少有运用任务态功能磁共振脑成像研究抑郁症情绪记忆加工性别差异的报道。本研究运用组块-事件相关混合设计功能磁共振成像研究单相抑郁症患者情绪记忆相关脑机制,并结合认知行为学检测,进一步探讨抑郁症情绪记忆相关性别差异的认知神经机制。 材料和方法抑郁症39名,其中男16名(平均38.4±2.57岁),女23名(平均37.2±2.32岁)。正常对照组44名,其中男23名(平均年龄22.43±0.31岁),女21名(平均年龄21.85±0.34岁)。实验材料包括120幅彩色情景图片,实验包括编码和立即提取两个阶段,编码阶段采用组块/事件相关混合设计方法。用3.0T MRI扫描并采集任务态功能数据,记录行为学成绩。利用MATLAB7.12、SPM、MRIcro和SPSS13.0统计软件包分别对fMRI数据及行为学数据进行相关统计分析。 结果(1)行为学结果显示:抑郁组男女对恐惧图片的平均反应正确率无显著性差异;女性对中性图片平均反应正确率明显低于男性(P0.05)。正常组对两种图片(恐惧或中性)的平均反应正确率没有性别的显著性差异。(2)功能磁共振成像结果:①抑郁症女性以瞬时效应为主,较男性主要激活脑区有:左侧额下回三角部、距状回、枕中回、右侧角回、尾状核、颞上回、枕中回及扣带回后部;男性以持续效应为主,较女性主要激活脑区有:双侧额下回岛盖,左侧内侧额上回、尾状核、岛回,右侧颞中回及内侧和旁扣带回。②交互作用分析显示:女性较男性瞬时效应显著增强脑区包括枕顶部皮层;男性较女性持续效应显著增强脑区包括额叶、扣带回及岛盖部。 结论 (1)抑郁症患者记忆认知功能下降,,情绪记忆增强效应仍保持。女性对中性事件记忆力显著下降,情绪记忆增强效应有所增加,而男性较正常人有所减弱。 (2)抑郁症情绪记忆相关脑区激活存在性别差异。女性瞬时效应相对增强,主要涉及枕顶部皮层;男性持续效应相对增强,主要涉及额叶、扣带回及岛盖部。
[Abstract]:Background and objective Depression (MDD) is an affective disorder characterized by depression. There is a gender difference in the incidence and prevalence of depression, with a ratio of about 1: 2. The cognitive neuromechanism of gender difference in depression has become one of the hotspots in neurology and brain science research at home and abroad. The structure and function of the brain area of gender difference in normal people have been confirmed by many studies. Using functional magnetic resonance imaging (fMRI), we found that there is a gender difference in the activation of amygdala associated with emotional memory, and whether this gender difference is related to the gender difference in patients with depression. Further study is needed. There are few reports at home and abroad on the gender differences in brain structure and resting functional magnetic resonance imaging (fMRI) in patients with depression, but there are few reports on the gender differences of emotional memory processing in depression using task-based functional magnetic resonance imaging (TfMRI). In this study, the motion-memory related brain mechanism of monophasic depression patients was studied by using block-event-related mixed design functional magnetic resonance imaging (fMRI), and cognitive behavior was measured. To further explore the cognitive neural mechanism of emotional memory related gender differences in depression. Materials and methods 39 patients with depression, including 16 males (mean 38.4 卤2.57 years) and 23 females (mean 37.2 卤2.32 years), were enrolled in this study. There were 44 normal controls, including 23 males (mean age 22.43 卤0.31) and 21 females (mean age 21.85 卤0.34). The experiment consists of 120 color scene images. The experiment consists of two stages: coding and immediate extraction. The coding stage adopts the mixed design method of block / event correlation. The functional data of task state were scanned with 3.0 T MRI and the behavioral scores were recorded. FMRI data and behavioral data were analyzed by MATLAB 7.12 SPSS13.0 MRIcro and SPSS13.0 software package respectively. Results (1) Behavioral results showed that there was no significant difference in the average correct rate of response to fear picture between male and female in depression group, and the average correct rate of response to neutral image in female was significantly lower than that in male (P0.05). There was no significant gender difference in the average correct rate of response to the two images (fear or neutral) in the normal group. (2) the results of functional magnetic resonance imaging showed that the transient effect was dominant in women with depression. The main activation areas were left inferior frontal gyrus, talar gyrus, middle occipital gyrus, right angular gyrus, caudate nucleus, superior temporal gyrus, middle occipital gyrus and posterior cingulate gyrus. The main activation areas in women were bilateral inferior frontal gyrus, left medial superior frontal gyrus, caudate nucleus, island gyrus, bilateral inferior frontal gyrus, left medial superior frontal gyrus, caudate nucleus, island gyrus. The interaction analysis of right middle temporal gyrus and medial and accessory cingulate gyrus showed that the transient effect of female was significantly enhanced than that of male, including occipital parietal cortex, and the sustained effect of male was significantly enhanced than that of female, including frontal lobe, cingulate gyrus and tegmental area. Conclusion (1) the memory cognitive function of depression patients decreased, while the effect of emotional memory enhancement remained. Female memory for neutral events decreased significantly, emotional memory increased, while male was weaker than normal. (2) there was a gender difference in the activation of depression emotional memory related brain area. The transient effect of female was relatively enhanced, mainly involving the occipital parietal cortex, while the male sustained effect was relatively enhanced, mainly involving the frontal lobe, cingulate gyrus and the tegmental part of the island.
【学位授予单位】:安徽医科大学
【学位级别】:硕士
【学位授予年份】:2013
【分类号】:R445.2;R749.4
本文编号:2150024
[Abstract]:Background and objective Depression (MDD) is an affective disorder characterized by depression. There is a gender difference in the incidence and prevalence of depression, with a ratio of about 1: 2. The cognitive neuromechanism of gender difference in depression has become one of the hotspots in neurology and brain science research at home and abroad. The structure and function of the brain area of gender difference in normal people have been confirmed by many studies. Using functional magnetic resonance imaging (fMRI), we found that there is a gender difference in the activation of amygdala associated with emotional memory, and whether this gender difference is related to the gender difference in patients with depression. Further study is needed. There are few reports at home and abroad on the gender differences in brain structure and resting functional magnetic resonance imaging (fMRI) in patients with depression, but there are few reports on the gender differences of emotional memory processing in depression using task-based functional magnetic resonance imaging (TfMRI). In this study, the motion-memory related brain mechanism of monophasic depression patients was studied by using block-event-related mixed design functional magnetic resonance imaging (fMRI), and cognitive behavior was measured. To further explore the cognitive neural mechanism of emotional memory related gender differences in depression. Materials and methods 39 patients with depression, including 16 males (mean 38.4 卤2.57 years) and 23 females (mean 37.2 卤2.32 years), were enrolled in this study. There were 44 normal controls, including 23 males (mean age 22.43 卤0.31) and 21 females (mean age 21.85 卤0.34). The experiment consists of 120 color scene images. The experiment consists of two stages: coding and immediate extraction. The coding stage adopts the mixed design method of block / event correlation. The functional data of task state were scanned with 3.0 T MRI and the behavioral scores were recorded. FMRI data and behavioral data were analyzed by MATLAB 7.12 SPSS13.0 MRIcro and SPSS13.0 software package respectively. Results (1) Behavioral results showed that there was no significant difference in the average correct rate of response to fear picture between male and female in depression group, and the average correct rate of response to neutral image in female was significantly lower than that in male (P0.05). There was no significant gender difference in the average correct rate of response to the two images (fear or neutral) in the normal group. (2) the results of functional magnetic resonance imaging showed that the transient effect was dominant in women with depression. The main activation areas were left inferior frontal gyrus, talar gyrus, middle occipital gyrus, right angular gyrus, caudate nucleus, superior temporal gyrus, middle occipital gyrus and posterior cingulate gyrus. The main activation areas in women were bilateral inferior frontal gyrus, left medial superior frontal gyrus, caudate nucleus, island gyrus, bilateral inferior frontal gyrus, left medial superior frontal gyrus, caudate nucleus, island gyrus. The interaction analysis of right middle temporal gyrus and medial and accessory cingulate gyrus showed that the transient effect of female was significantly enhanced than that of male, including occipital parietal cortex, and the sustained effect of male was significantly enhanced than that of female, including frontal lobe, cingulate gyrus and tegmental area. Conclusion (1) the memory cognitive function of depression patients decreased, while the effect of emotional memory enhancement remained. Female memory for neutral events decreased significantly, emotional memory increased, while male was weaker than normal. (2) there was a gender difference in the activation of depression emotional memory related brain area. The transient effect of female was relatively enhanced, mainly involving the occipital parietal cortex, while the male sustained effect was relatively enhanced, mainly involving the frontal lobe, cingulate gyrus and the tegmental part of the island.
【学位授予单位】:安徽医科大学
【学位级别】:硕士
【学位授予年份】:2013
【分类号】:R445.2;R749.4
【共引文献】
相关期刊论文 前1条
1 陈小静;吕厚超;李丹;敖灵敏;郭靖;;抑郁性别差异的新理论:ABC模型[J];中国健康心理学杂志;2010年11期
本文编号:2150024
本文链接:https://www.wllwen.com/yixuelunwen/jsb/2150024.html
最近更新
教材专著