小脑顶核电刺激对阿尔茨海默病神经元活动性的影响

发布时间：2018-08-02 08:01

【摘要】：目的:采用静息状态下血氧水平依赖功能磁共振(BOLD-fMRI)技术和低频振幅(ALFF)及比率低频振幅(fALFF)方法观察小脑顶核电刺激对阿尔茨海默病(AD)神经元活动性的影响。方法:将36例AD患者随机分为两组:治疗组18例,安慰治疗组18例,给予小脑顶核电刺激(FNS)治疗。治疗前后分别行静息态fMRI扫描,应用ALFF及fALFF方法分析脑功能区变化情况,采用统计学方法,比较治疗前后的差异。并且分别将治疗后的ALFF图及fALFF图与神经心理学检查量表评分作相关性分析。结果:FNS治疗后治疗组左侧小脑后叶、右侧小脑后叶、左侧海马/海马旁回、左侧后扣带回、左侧背外侧前额叶及右侧顶下小叶ALFF值升高,右侧顶下小叶fALFF值升高。安慰治疗组治疗后双侧小脑后叶及左侧后扣带回的ALFF值较治疗前降低。ADAS-Cog评分与治疗后左侧小脑后叶及右侧小脑后叶的ALFF值密切相关。结论:FNS能够改变AD患者部分脑区神经元的活动性。BOLD-fMRI信号的改变可为探索小脑顶核电刺激治疗AD的中枢机制提供潜在的影像学证据。
[Abstract]:Aim: to investigate the effects of apical nuclear stimulation on the activity of (AD) neurons in Alzheimer's disease using resting oxygen level dependent functional magnetic resonance (BOLD-fMRI) technique, low frequency amplitude (ALFF) and ratio low frequency amplitude (fALFF). Methods: 36 patients with AD were randomly divided into two groups: treatment group (n = 18) and consolation group (n = 18). The patients were treated with cerebellar fastigial nuclear stimulation (FNS). Resting fMRI scanning was performed before and after treatment. The changes of brain functional areas were analyzed by ALFF and fALFF. The differences before and after treatment were compared by statistical method. The correlation between ALFF and fALFF after treatment and the scores of neuropsychological examination scale were analyzed. Results the ALFF values of left posterior cerebellar lobe, right posterior cerebellar lobe, left hippocampal / parahippocampal gyrus, left posterior cingulate gyrus, left dorsolateral prefrontal lobe and right inferior parietal lobule increased in the treatment group. The ALFF scores of bilateral posterior cerebellar lobes and left posterior cingulate gyrus in the comfort treatment group were significantly lower than those before treatment. The ADAS-Cog score was closely related to the ALFF value of the left posterior cerebellar lobe and the right posterior cerebellar lobe. Conclusion the changes of brain neuronal activity. BOLD-fMRI signal can provide potential imaging evidence for exploring the central mechanism of cerebellar fastigial nuclear stimulation in the treatment of AD.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R749.16

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