艾司西酞普兰治疗惊恐障碍疗效和安全性的国内Meta分析

发布时间：2018-10-16 17:43

【摘要】：目的:探讨艾司西酞普兰治疗国内惊恐障碍患者的疗效和安全性。方法:应用Meta分析对12项艾司西酞普兰对照研究文献进行再分析,评价其合并效应量大小和综合显著性检验。结果:艾司西酞普兰治疗前后的自身对照显示,艾司西酞普兰治疗惊恐障碍2周后疗效变化显著(Tau2=4.06;95%CI:1.92,2.28;Z=5.90;P0.01)。艾司西酞普兰与对照药的比较结果表明,艾司西酞普兰2周起效(Tau2=0.42;95%CI:-1.35,-0.43;Z=3.82;P0.01);但终点疗效与对照药比较差异不显著(Tau2=6.04;95%CI:-0.20,0.05;Z=1.18)。安全性比较发现,艾司西酞普兰的不良反应少于其他抗抑郁剂,但差异不显著。结论:艾司西酞普兰治疗惊恐障碍起效快,安全性好。
[Abstract]:Objective: to investigate the efficacy and safety of Escitalopram in the treatment of panic disorder in China. Methods: 12 comparative studies of estalopram were reanalyzed by Meta analysis to evaluate the magnitude of combined effect and comprehensive significance test. Results: the self-control before and after the treatment of estalopram showed that the efficacy of Escitalopram was significantly changed (Tau2=4.06;95%CI:1.92,2.28;Z=5.90;P0.01) 2 weeks after treatment of panic disorder. The results of comparison of Escitalopram and control showed that estalopram was effective at 2 weeks (Tau2=0.42;95%CI:-1.35,-0.43;Z=3.82;P0.01), but the end effect was not significantly different from that of control (Tau2=6.04;95%CI:-0.20,0.05;Z=1.18). Safety comparison showed that escitalopram had less adverse reactions than other antidepressants, but the difference was not significant. Conclusion: Escitalopram is effective and safe in the treatment of panic disorder.
【作者单位】：天津医科大学;天津市安定医院心境障碍科;
【分类号】：R749.4

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