当前任务对慢性精神分裂症患者基于事件的前瞻性记忆的影响

发布时间：2018-11-05 09:48

【摘要】：目的:比较不同当前任务对慢性精神分裂症患者基于事件的前瞻性记忆(EBPM)的影响,探讨其EBPM的加工机制及特点。方法:选取符合精神障碍诊断与统计手册第4版(DSM-IV)诊断标准的慢性精神分裂症患者48例及正常对照51例,采用实验室PM范式,考察慢性精神分裂症患者及正常对照两组被试在图片材料、数字材料两种当前任务条件下的EBPM表现,统计正确率和反应时。结果:控制年龄影响后,精神分裂症组当前任务正确率、前瞻任务正确率均低于正常对照组[(90.3±12.6)%vs.(93.8±4.3)%,(78.3±29.9)%vs.(86.9±22.6)%;均P0.05];精神分裂症组当前任务反应时、前瞻任务反应时均长于正常对照组[(1700.4±501.4)ms vs.(1549.5±435.0)ms,(2514.8±842.1)ms vs.(2064.4±657.5)ms;均P0.05];当前任务不同对精神分裂症组及正常对照组前瞻任务正确率的影响不同(P0.05)。结论:慢性精神分裂症患者存在EBPM损害,慢性精神分裂症患者与正常对照对特定EBPM任务的加工方式存在差异,其EBPM自动加工过程存在一定程度的损伤。
[Abstract]:Aim: to compare the effects of different current tasks on event-based prospective memory (EBPM) in patients with chronic schizophrenia, and to explore the processing mechanism and characteristics of EBPM. Methods: 48 patients with chronic schizophrenia and 51 normal controls who were in accordance with the diagnostic criteria of the fourth edition (DSM-IV) of the Diagnostic and Statistical Manual for Mental Disorders and 51 normal controls were selected and used the laboratory PM paradigm. To investigate the EBPM performance, statistical accuracy and response time of patients with chronic schizophrenia and normal controls under two kinds of current task conditions: photo material and digital material. Results: after controlling the effect of age, the correct rate of current task and prospective task in schizophrenia group was lower than that in normal control group [(90.3 卤12.6)% vs. (93.8 卤4.3)%]. (78.3 卤29.9)% vs. (86.9 卤22.6%); The prospective task reaction time of schizophrenia group was significantly longer than that of normal control group [(1700.4 卤501.4) ms vs. (1549.5 卤435.0) ms, (2514.8 卤842.1) ms vs. (2064.4 卤657.5) ms;]. The effects of different tasks on the accuracy of prospective tasks in schizophrenia group and normal control group were different (P0.05). Conclusion: there is EBPM damage in patients with chronic schizophrenia, and there are differences in processing mode of specific EBPM tasks between patients with chronic schizophrenia and normal controls, and there is some damage in the process of EBPM automatic processing in patients with chronic schizophrenia.
【作者单位】：北京大学回龙观临床医学院;
【基金】：首都医学发展科研基金项目(计算机认知矫正治疗对老年轻度认知障碍的干预研究,2009-1056) 北京市科技计划项目(CRT改善精神分裂症患者认知功能的研究及机制探讨,编号D0906001040191)
【分类号】：R749.3

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