腔隙性脑梗死后非痴呆性血管性认知功能障碍的临床特点及影响因素研究

发布时间：2018-11-05 18:51

【摘要】：目的探讨腔隙性脑梗死(LI)后非痴呆性血管性认知功能障碍(VCIND)患者的临床特点及影响因素。方法选择2015年12月—2016年6月就诊于新疆医科大学第一附属医院神经内科的符合LI诊断标准的患者120例,参照认知相关神经量表进行评分,分为VCIND组(76例)和对照组(NC组,44例)。对两组的年龄、性别、受教育年限、高血压史、糖尿病史、高同型半胱氨酸血症史、短暂性脑缺血发作史、吸烟史、饮酒史、头颈动脉狭窄程度、脑白质病变评分及认知功能评分进行比较,分析上述因素与LI后VCIND的关系。结果两组患者的年龄、受教育年限、高血压史、简易精神状态检查量表(MMSE)评分、蒙特利尔认知评估量表(Mo CA)评分比较,差异均有统计学意义(P0.05)。NC组患者的头颈动脉狭窄程度、深部脑白质高信号评分均优于VCIND组(P0.05)。头颈动脉狭窄程度为3、4级,深部脑白质高信号评分为3分是LI后VCIND的危险因素,受教育年限是LI后VCIND的保护因素(P0.05)。结论 LI后VCIND患者的认知功能在视空间和执行功能、命名、注意力、抽象、延迟回忆、定向力方面存在损害,头颈部动脉狭窄程度为3、4级和严重的深部脑白质病变与LI后VCIND患者的认知功能损害相关。
[Abstract]:Objective to investigate the clinical features and influencing factors of non-dementia vascular cognitive dysfunction (VCIND) after lacunar cerebral infarction (LI). Methods from December 2015 to June 2016, 120 patients in the Department of Neurology, first affiliated Hospital of Xinjiang Medical University, who met the diagnostic criteria of LI, were divided into VCIND group (76 cases) and control group (NC group). 44 cases). Age, sex, years of education, history of hypertension, history of diabetes, history of hyperhomocysteinemia, history of transient ischemic attack, history of smoking, history of alcohol consumption, degree of stenosis of head and neck artery, The white matter lesion score and cognitive function score were compared to analyze the relationship between the above factors and VCIND after LI. Results the age, years of education, history of hypertension, (MMSE) score of mini-mental state examination scale and (Mo CA) score of Montreal Cognitive Assessment scale were compared between the two groups. The difference was statistically significant (P0.05) in). NC group, the degree of stenosis of the head and neck artery, the high signal score of white matter in the deep brain were better than those in the VCIND group (P0.05). The degree of stenosis of the head and carotid artery was 3 ~ 4 grade, the high signal score of white matter in the deep brain was 3, which was the risk factor of VCIND after LI, and the years of education was the protective factor of VCIND after LI (P0.05). Conclusion the cognitive function of VCIND patients after LI is impaired in visual space, executive function, naming, attention, abstraction, delayed recall and orientation. The severity of arterial stenosis in the head and neck was 3 ~ 4 grade and severe deep white matter lesions were associated with cognitive impairment in VCIND patients after LI.
【作者单位】：新疆医科大学第一附属医院神经内科;新疆维吾尔自治区中医医院神经内科;
【基金】：新疆维吾尔自治区自然科学基金资助项目(2015211C085)
【分类号】：R749.13

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