丁苯酞对老年血管性痴呆患者认知功能的影响

发布时间：2018-12-09 20:49

【摘要】：目的探究丁苯酞对老年血管性痴呆(VD)患者认知功能的影响及可能机制。方法选择122例老年VD患者,采用不同的治疗方法进行研究,比较两组患者治疗前及疗程结束后血清超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量、血浆转化生长因子(TGF)-β、细胞间黏附分子(ICAM)-1、胰岛素样生长因子(IGF)-1水平、生活质量评分、精神心理量表得分及治疗效果。结果治疗后,两组各项血清及血浆指标均有所改变,治疗组改变更明显,两组生活质量均有所改善,治疗组评分改善情况较对照组更明显,两组简易精神状态量表(MMSE)、临床痴呆程度量表(CDR)得分均有改变,治疗组评分改善情况更明显(均P0.05),治疗组治疗总效率(95.31%)明显优于对照组(81.25%,P0.05)。结论丁苯酞有助于改善老年VD患者认知功能,安全有效、作用机制可能与抗氧化,减少氧自由基及炎症因子,保护脑组织细胞有关。
[Abstract]:Objective to investigate the effect of butyphthalide on cognitive function of senile vascular dementia patients with (VD) and its possible mechanism. Methods the serum superoxide dismutase (SOD) activity and malondialdehyde (MDA) content were compared between the two groups before and after treatment in 122 elderly patients with VD. Plasma levels of transforming growth factor (TGF)-尾, intercellular adhesion molecule (ICAM)-1, insulin-like growth factor (IGF)-1, quality of life (QOL) scores, mental and psychological scale scores and therapeutic effects. Results after treatment, the indexes of serum and plasma were changed in both groups, especially in the treatment group, and the quality of life was improved in both groups. The improvement of scores in the treatment group was more obvious than that in the control group. The (MMSE), of the two groups was more obvious than that of the control group. The (CDR) scores of the clinical dementia scale were all changed, the improvement of the treatment group was more obvious (P0.05), the total treatment efficiency of the treatment group (95.31%) was significantly better than that of the control group (81.25%, P0.05). Conclusion Butylphthalide can improve cognitive function of elderly patients with VD. The mechanism may be related to anti-oxidation, reducing oxygen free radicals and inflammatory factors, and protecting brain tissue and cells.
【作者单位】：宁波市鄞州第二医院神经内科;
【分类号】：R749.13

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