老年人认知功能减退知情者问卷判断阿尔茨海默病患者严重程度的效度

发布时间：2018-12-26 08:47

【摘要】：目的:评价老年人认知功能减退知情者问卷(IQCODE)区分阿尔茨海默病(AD)患者认知功能损害程度的有效性。方法:收集来院就诊的AD患者332例,按临床痴呆程度标准分为轻、中、重度组,应用简短版本的老年人认知功能减退知情者问卷(IQCODE)对其知情者进行问卷调查。分析各组IQCODE得分与简明精神状态量表(MMSE)、Mattis痴呆评定量表(DRS)、阿尔茨海默病评估量表-认知部分(ADAS-Cog)得分的相关性,检验其区分不同认知功能损害程度的效度。结果:IQCODE与MMSE、DRS、ADAS-cog的相关系数分别为-0.512、-0.478和0.522。以65分作为划界分区分轻-中度痴呆,敏感性为66.9%,特异性为57.3%;以75分作为划界分区分中-重度痴呆,敏感性为73.8%,特异性为66.9%。结论:IQCODE可以中等有效地区分不同程度的认知功能障碍,但单独使用准确性欠佳,建议临床结合其他痴呆量表使用,以提高评定效能。
[Abstract]:Objective: to evaluate the effectiveness of (IQCODE) questionnaire in differentiating the degree of cognitive impairment in (AD) patients with Alzheimer's disease. Methods: 332 patients with AD were divided into mild, moderate and severe groups according to the standard of clinical dementia. A brief version of (IQCODE) questionnaire was used to investigate the informants of the patients with cognitive impairment. To analyze the correlation between IQCODE score and (DRS), Alzheimer's disease assessment scale (ADAS-Cog) of brief mental state scale (MMSE), Mattis), and to test its validity in differentiating different degree of cognitive impairment. Results: the correlation coefficients between IQCODE and MMSE,DRS,ADAS-cog were -0.512 ~ -0.478 and 0.522 respectively. The sensitivity was 66.9, the specificity was 57.3, the sensitivity was 73.8 and the specificity was 66.9. Conclusion: IQCODE can effectively distinguish different degree of cognitive dysfunction, but the accuracy of using it alone is not good. It is suggested that IQCODE should be used in combination with other dementia scales in order to improve the evaluation efficacy.
【作者单位】：靖江市人民医院;复旦大学附属华山医院;
【分类号】：R749.16

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