迷迭香吸嗅在脑梗死后认知障碍中的临床观察

发布时间：2019-01-12 09:54

【摘要】：目的观察迷迭香吸嗅方法在脑梗死后认知障碍患者中的干预效果。方法选取脑梗死后存在认知障碍的患者66例，随机分为三组，分别为吸嗅组、奥拉西坦组和对照组，每组均为22例。三组均给予常规治疗，包括控制合并症，预防并发症，康复功能训练，物理因子治疗以及活血扩管药物治疗等。在此基础上，吸嗅组予以迷迭香提取物吸嗅，0.4mL，用20ml常温纯净水稀释后放人扩香仪托盘中，放在50cm×40cm×30cm的密闭塑料盒中，利用灯泡加热，使用鼻导管一端开口于塑料盒，另一端放在患者鼻孔内，吸入时间为30min，每天三次。奥拉西坦组予以奥拉西坦静滴4g溶于250ml生理盐水或5%葡萄糖水中，静滴，每天一次。对照组予以常规治疗外，不予特殊处理。三组疗程均为4w。分别在干预前、干预2w、干预4w用MMSE（Mini-mental State Examination）及MBI（ModifiedBarthel Index）对三组患者进行评定及疗效评估，并记录数据。数据结果应用SPSS17.0软件进行统计学分析。结果①吸嗅组MMSE评分干预前后分别为13.18±3.83（干预前），16.72±2.93（干预2W），18.50±3.11（干预4w），MBI评分干预前后分别为41.04±6.33（干预前），54.54±6.70（干预2w），68.22±5.98（干预4w）。奥拉西坦组MMSE评分干预前后分别为11.90±4.15（干预前），17.13±4.34（干预2w），19.45±3.71（干预4w），MBI评分干预前后分别为39.18±4.96（干预前），53.50±6.02（干预2w），66.45±5.30（干预4w）。对照组MMSE评分分别为12.54±3.20（干预前），13.31±3.42（干预2w），14.72±3.46（干预4w），，MBI评分干预前后分别为39.31±5.25（干预前），48.31±4.33（干预2w），59.04±3.65（干预4w）。②吸嗅组和奥拉西坦组干预2w、4w的MMSE评分均较干预前升高（P0.05），而对照组干预前后的MMSE评分不具有统计学意义（P0.05）,两组干预2w及4w的评分分别与对照组相比有统计学差异（P0.05），且MMSE评分吸嗅组与奥拉西坦组比较无统计学差异（P0.05)，但奥拉西坦组总有效率（86.36%）较吸嗅组（72.27%）高。③3组的MBI评分干预2w，4w均较干预前升高（P0.05），吸嗅组与奥拉西坦组的评分和对照组比较升高更明显，且有统计学差异（P0.05）结论①常规的康复治疗结合迷迭香吸嗅具有改善脑梗死后认知障碍患者的认知功能及日常生活活动能力的近期疗效。②脑梗死患者认知功能的改善程度与日常生活活动能力密切相关，说明改善认知功能可提高脑梗死患者的日常生活活动能力，提高康复治疗效果。
[Abstract]:Objective to observe the effect of rosemary sniffing in patients with cognitive impairment after cerebral infarction. Methods Sixty-six patients with cognitive impairment after cerebral infarction were randomly divided into three groups: olfactory sniffing group, oxiracetam group and control group, with 22 cases in each group. All the three groups were given routine treatment, including control of complications, prevention of complications, rehabilitation training, physical factor therapy and drug therapy for promoting blood circulation. On this basis, rosemary extract was given in the sniffing group, 0.4 mL, diluted with 20ml pure water at room temperature, placed in the sealed plastic box of 50cm 脳 40cm 脳 30cm, heated by light bulb, and opened at one end of nose tube in plastic box. Place the other end in the nostrils for 30 mins, three times a day. In the oxiracetam group, 4 g of oxiracetam was given intravenously in 250ml saline or 5% glucose solution, once a day. The control group was given routine treatment, without special treatment. All the three groups were treated for 4 ws. MMSE (Mini-mental State Examination) and MBI (ModifiedBarthel Index) were used to evaluate and evaluate the curative effect of the three groups before and after intervention for 2 weeks and 4 weeks, and the data were recorded. The data were analyzed by SPSS17.0 software. Results 1the MMSE score of the sniffing group was 13.18 卤3.83 (before intervention), 16.72 卤2.93 (intervention 2W), 18.50 卤3.11 (), MBI score 4w) before and after intervention, respectively (41.04 卤6.33 before intervention). 54.54 卤6.70 (2 weeks), 68.22 卤5.98 (4 weeks). The MMSE scores before and after intervention were 11.90 卤4.15 (pre-intervention), 17.13 卤4.34 (2 weeks) and 19.45 卤3.71 (39.18 卤4.96 before and after 4 weeks of intervention) in olaxetam group, respectively. 53.50 卤6.02 (2 weeks), 66.45 卤5.30 (4 weeks). The MMSE scores of the control group were 12.54 卤3.20 (before intervention), 13.31 卤3.42 (intervention 2 weeks), 14.72 卤3.46 (before and after 4 weeks intervention), 39.31 卤5.25 (before intervention) and 48.31 卤4.33 (intervention 2 weeks), respectively. 59.04 卤3.65 (4w). 2 the MMSE scores of the olfactory suction group and olaxetam group were higher than those before and after intervention (P0.05), but the MMSE scores of the control group were not statistically significant (P0.05). The scores of 2 weeks and 4 weeks of intervention in the two groups were significantly different from those in the control group (P0.05), and there was no significant difference in MMSE score between the olfactory suction group and olaxetam group (P0.05). However, the total effective rate of oloxetam group (86.36%) was higher than that of sniffing group (72.27%). The MBI score of 33 group was significantly higher than that of pre-intervention group (P0.05), and the score of olfactory suction group and oloxetam group was higher than that of control group. And there was significant difference (P0.05) conclusion: 1 routine rehabilitation therapy combined with rosemary sniffing can improve cognitive function and daily living ability of patients with cognitive impairment after cerebral infarction. 2 recent curative effect of cerebral infarction. The improvement of patients' cognitive function is closely related to their activities of daily life. It shows that improving cognitive function can improve the activity of daily life of patients with cerebral infarction and improve the effect of rehabilitation treatment.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R749.13

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