成年人鱼类的摄入与抑郁关系的研究

发布时间：2019-01-12 18:59

【摘要】：目的:鱼类摄入与抑郁症之间的关系目前尚不明确。本文通过一个meta分析和一个现况研究来探讨不同种类鱼的摄入和抑郁症之间的关系。方法:我们在meta分析中对Pub Med,Embase和Web of Science三个数据库进行文献检索,采用随机效应模型合并相对危险度(RR)及其95%置信区间(95%CI),之后进行meta回归和亚组分析来探索异质性来源,最后用Egger线性回归法和漏斗图检测发表偏倚。现况研究的数据来自2005-2012年内的美国国民健康和营养体格检查的20201个成人样本(所有研究对象年龄均大于等于18周岁),采用单因素卡方检验和Mantel-Haenszel(M-H)分层卡方检验分析不同种类鱼的摄入与抑郁症之间的关系,Logistic回归模型被用来估计比值比(OR)以及其95%CI。结果:Meta分析一共纳入了26个研究包括150278个研究对象,相对于低的鱼类摄入来说,高的鱼类摄入与抑郁症之间的合并RR值是0.83(95%CI 0.74-0.93)。该结果在队列研究(RR=0.84,95%CI 0.75-0.94,n=10)和横断面研究(RR=0.82,95%CI 0.68-1.00,n=16)中都有意义。现况研究共有研究对象20201人,平均年龄47.24±18.95岁。其中患抑郁症的有4850人,占总人数的24.01%。单因素卡方检验显示总的鱼类摄入、海鱼摄入与抑郁症之间有显著的负相关关系,海鱼中的偏口鱼、黑线鳕鱼、三文鱼、海鲈鱼、剑鱼、明太鱼是有意义的保护因素,而面包鱼是有意义的危险因素;淡水鱼中的河鲈鱼是有意义的危险因素,鳟鱼是有意义的保护因素。分别控制年龄和性别的M-H卡方检验显示,结果并未有明显改变。多因素logistic回归显示,三文鱼的摄入与轻度和中重度抑郁症之间有显著的负相关关系,面包鱼对轻度和中重度抑郁症有显著的正相关关系,其他鱼类如金枪鱼、大口黑鲈、偏口鱼、剑鱼和明太鱼与中重度抑郁症之间有统计学意义的负相关关系,而河鲈鱼与轻度抑郁症之间有统计学意义的正相关关系。结论:meta结果表明总的鱼类摄入可以降低抑郁症的患病风险,现况研究分析表明,摄入海鱼可以对抑郁症起到保护作用,其中三文鱼摄入对轻度抑郁症和中重度抑郁症都有保护作用,河鲈鱼和面包鱼可能是抑郁症的危险因素。
[Abstract]:Objective: the relationship between fish intake and depression is unclear. A meta analysis and a status study were used to investigate the relationship between intake and depression in different species of fish. Methods: three databases of Pub Med,Embase and Web of Science were searched in the meta analysis. The random effect model was used to combine the relative risk (RR) and its 95% confidence interval (95%CI). Then meta regression and subgroup analysis were performed to explore the source of heterogeneity. Finally Egger linear regression and funnel plot were used to detect publication bias. The data from the status study came from 20,201 adult samples of the United States National Health and Nutrition physical examination for the period 2005-2012 (all subjects were older than 18 years of age). Univariate chi-square test and Mantel-Haenszel (M-H) stratified chi-square test were used to analyze the relationship between the intake of different species of fish and depression. The Logistic regression model was used to estimate the ratio of (OR) and 95 CIs. Results: a total of 26 studies including 150278 subjects were included in Meta analysis. The combined RR value between high fish intake and depression was 0.83 (95%CI 0.74-0.93) compared with low fish intake. The results are significant in both cohort study (RR=0.84,95%CI 0.75-0.94) and cross-sectional study (RR=0.82,95%CI 0.68-1.00 n ~ (16). A total of 20201 subjects with an average age of 47.24 卤18.95 years were enrolled in the present study. Of these, 4850 people suffered from depression, accounting for 24.01 percent of the total. Univariate chi-square test showed that there was a significant negative correlation between total fish intake, sea fish intake and depression. Bread fish is a significant risk factor; River bass in freshwater fish is a significant risk factor and trout is a significant protective factor. M-H chi-square test, which controlled age and sex, showed no significant change. Multivariate logistic regression analysis showed that there was a significant negative correlation between intake of salmon and mild and moderate depression. Bread fish had a significant positive correlation with mild and moderate depression. There was a significant negative correlation between bigmouth, swordfish and minnow and moderate and severe depression, while there was a positive correlation between river bass and mild depression. Conclusion: meta results show that total fish intake can reduce the risk of depression. Salmon intake has protective effects on mild depression and moderate and severe depression, and river bass and bread fish may be risk factors of depression.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R749.4

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