单胺氧化酶体受虐在新A基因rs1137070多态性与儿童期躯疆酒精依赖患者家庭暴力发生中的交互作用

发布时间：2019-03-05 15:28

【摘要】：目的探讨单胺氧化酶A(monoamine oxidase A,MAOA)rs1137070基因多态性与儿童期躯体受虐因素的交互作用对酒精依赖患者家庭暴力行为的影响。方法对284例新疆地区酒精依赖患者进行问卷调查,通过家庭暴力问卷调查表获得社会人口学资料、施暴(有或无)及施暴的表现形式,采用修改版外显行为攻击量表和修订版Barratt冲动量表对攻击行为进行评估并分组,采用儿童受虐筛查表与儿童受虐量表联合调查儿童期躯体受虐情况。直接测序法检测患者MAOA基因rs1137070位点的多态性。根据叉生分析相加模型交互作用指标判断基因与儿童期躯体受虐因素的交互作用。结果施暴组和对照组分别为146例和138例患者。儿童期受虐与rs1137070位点等位基因是新疆汉族及维吾尔族酒精依赖患者家庭暴力行为的危险因素。儿童期受虐与rs1137070等位基因存在相加模型正交互作用,两者的超额相对危险度、交互作用归因比、交互作用指数分别为1.00、0.14和1.20。结论新疆汉族及维吾尔族酒精依赖患者家庭暴力行为的发生是儿童期受虐因素及遗传危险因素共同作用的结果,儿童期受虐因素与rs1137070等位基因共同影响家庭暴力行为的发生。
[Abstract]:Aim to investigate the interaction between monoamine oxidase (A (monoamine oxidase A, maa) rs1137070 gene polymorphism and childhood physical abuse factors on the behavior of domestic violence in alcohol dependent patients. Methods 284 patients with alcohol dependence in Xinjiang were investigated by questionnaire. Social demographic data were obtained through the questionnaire of domestic violence, and the forms of violence (with or without) and the forms of violence were obtained. The aggressive behavior was evaluated by modified explicit behavior aggression scale and revised Barratt Impulse scale. Child abuse screening scale and Child abuse scale were used to investigate the physical abuse in children. The polymorphism of rs1137070 locus of MAOA gene was detected by direct sequencing. According to the interaction index of the additive model of cross-birth analysis, the interaction between gene and childhood physical abuse factors was judged. Results there were 146 cases in the violence group and 138 cases in the control group. Childhood abuse and rs1137070 allele are risk factors for domestic violence in alcohol dependent patients of Han and Uygur nationalities in Xinjiang. There was a positive interaction between childhood masochism and rs1137070 allele, the excess relative risk and the ratio of interaction attribution were 1.00, 0.14 and 1.20, and the interaction index was 1.00, 0.14 and 1.20, respectively. Conclusion the occurrence of domestic violence in alcohol dependent patients of Han and Uygur nationalities in Xinjiang is the result of childhood abuse factors and genetic risk factors. Childhood abuse factors and rs1137070 allele together affect the occurrence of domestic violence. [WT5 "HZ] conclusion [WT5" BZ] [WT5 "BZ]
【作者单位】：新疆维吾尔自治区人民医院临床心理科;新疆维吾尔自治区人民医院科研教育中心;新疆精神卫生中心戒酒科;
【基金】：国家自然科学基金项目(编号:31060137)
【分类号】：R749.62

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