头发、血浆皮质醇水平变化与抑郁症的相关性研究
发布时间：2019-05-13 17:17
【摘要】：目的探讨头发、血浆皮质醇水平在抑郁症发病过程中的特点及抗抑郁治疗前后的变化。方法纳入抑郁症患者47例和正常对照47名。抑郁症组给予选择性5-羟色胺再摄取抑制剂治疗4周,分别于治疗前、治疗4周后检测头发、血浆皮质醇水平,分别采用汉密尔顿抑郁量表17项(Hamilton Depression Rating Scale-17,HAMD-17)和汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)评估抑郁症状和焦虑症状的严重程度及疗效。对照组不予干预,于入组时检测头发、血浆皮质醇水平。结果抑郁症组治疗前头发皮质醇水平高于对照组[(17.42±12.40)nmol/L vs.(10.22±8.00)nmol/L,P0.01],血浆皮质醇水平两组间无统计学差异(P0.05)。抑郁症组治疗后HAMD-17总分[(10.60±4.57)vs.(24.00±4.86)]和HAMA总分[(6.30±4.86)vs.(15.78±5.45)]较治疗前均降低(P0.01),治疗后头发皮质醇水平较治疗前增高[(30.53±25.75)nmol/L vs.(16.02±11.77)nmol/L,P0.05],血浆皮质醇水平治疗前后差异无统计学意义(P0.05)。治疗后达到临床痊愈的患者治疗前血浆皮质醇水平高于非临床痊愈的患者[(27.47±14.48)nmol/L vs.(18.30±7.11)nmol/L,P0.05]。抑郁症组治疗前血浆皮质醇水平与HAMD-17中的胃肠道症状因子分呈正相关(r=0.335,P=0.023),与HAMD-17总分及其他因子的相关性均无统计学意义(P0.05)。结论抑郁症患者头发皮质醇水平高于正常对照,经抗抑郁药治疗后头发皮质醇水平较治疗前升高。治疗前血浆皮质醇水平高的患者可能对抗抑郁药治疗更敏感,可获得更好的临床疗效。
[Abstract]:Objective to investigate the characteristics of hair and plasma cortisol levels in the pathogenesis of depression and the changes of cortisol levels before and after antidepressant treatment. Methods 47 patients with depression and 47 normal controls were included. The depression group was treated with selective serotonin reuptake inhibitor for 4 weeks. Hair and plasma cortisol levels were measured before and 4 weeks after treatment. Hamilton depression scale 17 items (Hamilton Depression Rating Scale-17, were used respectively. HAMD-17) and Hamilton anxiety scale (Hamilton anxiety scale,HAMA) were used to evaluate the severity and efficacy of depression and anxiety. The control group did not intervene, and the levels of cortisol in hair and plasma were measured at the time of admission. Results the level of cortisol in hair of depression group was higher than that of control group before treatment [(17.42 卤12.40) nmol/L vs. (10.22 卤8.00) nmol/L,P0.01], but there was no significant difference in plasma cortisol level between the two groups (P 0.05). After treatment, the total scores of HAMD-17 and HAMA in depression group [(10.60 卤4.57) vs. (24.00 卤4.86)] and (6.30 卤4.86) vs. (15.78 卤5.45) were lower than those before treatment (P 0.01). After treatment, the level of cortisol in hair was higher than that before treatment [(30.53 卤25.75) nmol/L vs. (16.02 卤11.77) nmol/L,P0.05], but there was no significant difference in plasma cortisol level before and after treatment (P 0.05). The plasma cortisol level in patients with clinical recovery after treatment was higher than that in patients with non-clinical recovery [(27.47 卤14.48) nmol/L vs. (18.30 卤7.11) nmol/L,P0.05]. In depression group, plasma cortisol level was positively correlated with gastrointestinal symptom factor score in HAMD-17 before treatment (r 鈮，
本文编号：2476057
[Abstract]:Objective to investigate the characteristics of hair and plasma cortisol levels in the pathogenesis of depression and the changes of cortisol levels before and after antidepressant treatment. Methods 47 patients with depression and 47 normal controls were included. The depression group was treated with selective serotonin reuptake inhibitor for 4 weeks. Hair and plasma cortisol levels were measured before and 4 weeks after treatment. Hamilton depression scale 17 items (Hamilton Depression Rating Scale-17, were used respectively. HAMD-17) and Hamilton anxiety scale (Hamilton anxiety scale,HAMA) were used to evaluate the severity and efficacy of depression and anxiety. The control group did not intervene, and the levels of cortisol in hair and plasma were measured at the time of admission. Results the level of cortisol in hair of depression group was higher than that of control group before treatment [(17.42 卤12.40) nmol/L vs. (10.22 卤8.00) nmol/L,P0.01], but there was no significant difference in plasma cortisol level between the two groups (P 0.05). After treatment, the total scores of HAMD-17 and HAMA in depression group [(10.60 卤4.57) vs. (24.00 卤4.86)] and (6.30 卤4.86) vs. (15.78 卤5.45) were lower than those before treatment (P 0.01). After treatment, the level of cortisol in hair was higher than that before treatment [(30.53 卤25.75) nmol/L vs. (16.02 卤11.77) nmol/L,P0.05], but there was no significant difference in plasma cortisol level before and after treatment (P 0.05). The plasma cortisol level in patients with clinical recovery after treatment was higher than that in patients with non-clinical recovery [(27.47 卤14.48) nmol/L vs. (18.30 卤7.11) nmol/L,P0.05]. In depression group, plasma cortisol level was positively correlated with gastrointestinal symptom factor score in HAMD-17 before treatment (r 鈮，
本文编号：2476057
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