阿戈美拉汀联合认知行为干预对缺血性脑卒中后抑郁患者再发脑卒中的影响
发布时间：2019-07-11 18:47
【摘要】：目的探讨阿戈美拉汀联合认知行为干预对缺血性脑卒中后抑郁患者再发脑卒中的影响。方法首次诊断治疗的脑卒中后抑郁患者114例随机分为对照组和观察组各57例。对照组采用艾司西酞普兰配合认知行为干预,观察组服用阿戈美拉汀联合认知行为干预,两组均治疗3个月并配合完成6个月随访。观察记录两组脑卒中再发率及治疗前后汉密尔顿抑郁(HAMD)评分、副反应量表(TESS)评分。结果治疗后,两组HAMD评分均显著改善,且观察组改善效果显著优于对照组(P0.05)。对照组脑卒中再发率(17.54%)显著高于观察组(8.77%)(P0.05)。两组用药后均出现不良反应,观察组激越、出汗发生率明显少于对照组,且观察组TESS评分〔(3.15±0.98)分〕显著低于对照组〔(4.02±1.05)分〕(均P0.05)。结论阿戈美拉汀配合认知行为干预对脑卒中后抑郁患者具有较好的抗抑郁及神经保护作用,且不良反应较少,安全性好。
[Abstract]:Objective to investigate the effect of agometine combined with cognitive behavior intervention on recurrent stroke in patients with post-ischemic stroke depression. Methods 114 patients with post-stroke depression diagnosed and treated for the first time were randomly divided into control group (n = 57) and observation group (n = 57). The control group was treated with escitalopram combined with cognitive behavior intervention, and the observation group was treated with agometine combined with cognitive behavior intervention. Both groups were treated for 3 months and followed up for 6 months. The recurrence rate of stroke, Hamilton depression (HAMD) score and side effect scale (TESS) score before and after treatment were observed and recorded. Results after treatment, the HAMD scores of the two groups were significantly improved, and the improvement effect of the observation group was significantly better than that of the control group (P 0.05). The recurrence rate of stroke in the control group (17.54%) was significantly higher than that in the observation group (8.77%) (P 0.05). The incidence of sweating in the observation group was significantly lower than that in the control group, and the TESS score in the observation group (3.15 卤0.98) was significantly lower than that in the control group (4.02 卤1.05) (P 0.05). Conclusion Agomelatine combined with cognitive behavior intervention has good antidepressant and neuroprotective effects on post-stroke depression patients, and the adverse reactions are less and the safety is good.
【作者单位】： 海南省安宁医院;
【基金】：海南省自然科学基金项目(No.812163)
【分类号】：R749.13
本文编号：2513389
[Abstract]:Objective to investigate the effect of agometine combined with cognitive behavior intervention on recurrent stroke in patients with post-ischemic stroke depression. Methods 114 patients with post-stroke depression diagnosed and treated for the first time were randomly divided into control group (n = 57) and observation group (n = 57). The control group was treated with escitalopram combined with cognitive behavior intervention, and the observation group was treated with agometine combined with cognitive behavior intervention. Both groups were treated for 3 months and followed up for 6 months. The recurrence rate of stroke, Hamilton depression (HAMD) score and side effect scale (TESS) score before and after treatment were observed and recorded. Results after treatment, the HAMD scores of the two groups were significantly improved, and the improvement effect of the observation group was significantly better than that of the control group (P 0.05). The recurrence rate of stroke in the control group (17.54%) was significantly higher than that in the observation group (8.77%) (P 0.05). The incidence of sweating in the observation group was significantly lower than that in the control group, and the TESS score in the observation group (3.15 卤0.98) was significantly lower than that in the control group (4.02 卤1.05) (P 0.05). Conclusion Agomelatine combined with cognitive behavior intervention has good antidepressant and neuroprotective effects on post-stroke depression patients, and the adverse reactions are less and the safety is good.
【作者单位】： 海南省安宁医院;
【基金】：海南省自然科学基金项目(No.812163)
【分类号】：R749.13
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1 许瑞芹;李旭;胡庆秀;;强迫障碍病人的认知行为干预效果观察[J];全科护理;2012年19期
，本文编号：2513389
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