牙槽嵴位点保存的动物实验研究

发布时间：2018-01-30 01:11

本文关键词： 牙槽嵴位点保存 Bio-Oss Collagen 即刻种植骨吸收　出处：《实用医学杂志》2014年12期 　论文类型：期刊论文

【摘要】：目的:评估经位点保存方法处理过的拔牙窝与自然愈合位点相比其牙槽骨骨量在组织形态计量学上的变化。方法:拔除6只Beagle犬双侧下颌第二、第三及第四前磨牙(Pm2、Pm3、Pm4),随机分成3组:自然愈合组(T1),Bio-Oss Collagen组(T2),即刻种植联合Bio-Oss骨粉组(T3)。6个月后处死Beagle犬,切取样本,制作硬组织磨片,甲苯胺蓝染色后在光学显微镜下利用图像分析软件进行组织学观察及形态学测量。结果:所有实验位点颊侧牙槽嵴都发生明显的吸收。对于颊舌侧牙槽嵴顶吸收的相对高度值而言,T3与T1、T2组之间差异均有统计学意义(P0.001),而T1与T2组间差异无统计学意义。对于颊舌侧骨壁的水平宽度值而言,在距舌侧牙槽嵴顶以下3、4 mm的位置,T1与T3组间差异均具有统计学意义(P=0.017,P=0.042),其他组间差异均无统计学意义。在距舌侧牙槽嵴顶以下5 mm的位置,3组间的差异均无统计学意义。结论:这两种牙槽嵴位点保存技术都不能完全保存拔牙窝原有的骨量。即刻种植联合Bio-Oss骨粉可以在一定程度上减少牙槽嵴吸收的量,而充填Bio-Oss骨胶原效果欠佳。
[Abstract]:Objective: to evaluate the histomorphometric changes of alveolar bone in the extraction fossa treated by site preservation method compared with the natural healing site. Methods: the second mandible of 6 Beagle dogs was extracted. The third and fourth premolars were randomly divided into 3 groups: natural healing group (T1) and Bio-Oss Collagen group (T2). After 6 months, Beagle dogs were killed, samples were taken and hard tissue grinding was made. After toluidine blue staining, histological observation and morphological measurement were carried out by using image analysis software under optical microscope. The buccal alveolar ridge was significantly absorbed in all experimental sites, and the relative height of buccal and lingual alveolar crest resorption was observed. There were significant differences between T 3 and T 1 T 2 groups (P 0.001), but there was no significant difference between T 1 and T 2 groups. For the horizontal width of buccal and lingual bone wall, there was no significant difference between T 3 and T 1 T 2 groups. There were significant differences between T _ 1 and T _ 3 groups at 3 ~ 4 mm below the lingual alveolar crest (P < 0.017). There was no significant difference between the other groups. The distance from the lingual alveolar crest to the top of the alveolar crest was 5 mm. There was no significant difference among the three groups. Conclusion:. Neither of these two methods can completely preserve the original bone mass of extraction nest. Immediate implantation combined with Bio-Oss bone powder can reduce the amount of alveolar ridge absorption to some extent. However, the effect of filling Bio-Oss bone collagen was not good.
【作者单位】：南方医科大学附属口腔医院.广东省口腔医院;
【基金】：广东省科技计划重点引导项目(编号:2010B03160011) 广东省医学科学技术研究基金(编号:A2012104)
【分类号】：R782.12
【正文快照】： 牙齿拔除后,牙槽嵴的宽度和高度均会发生显著吸收,且颊侧骨壁的吸收远远高于舌侧骨壁[1],有学者发现,拔牙后1年内,牙槽骨宽度吸收可达50%,高度吸收可达40%[2]。牙槽嵴位点保存的目的是在拔牙后能有效地保存原有牙槽嵴的高度、宽度以及相应软组织量,为随后的种植修复提供良好

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