牙周炎与高血压前期的相关性研究

发布时间：2018-03-01 06:02

本文关键词： 牙周炎高血压前期炎性细胞因子相关性　出处：《临床心血管病杂志》2016年01期 　论文类型：期刊论文

【摘要】：目的:了解牙周炎患者高血压前期的发病情况,分析牙周炎的严重程度与高血压前期的关系,探讨炎性细胞因子在牙周炎伴高血压前期中的作用。方法:对310例牙周炎患者进行血压测量和牙周检查,调查牙周炎患者高血压前期的发病情况,分析轻、中、重度牙周炎与高血压前期的关系;随机选择单纯牙周炎43例,牙周炎伴高血压前期40例,伴高血压38例,测定受试者血清中的超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)和肿瘤坏死因子(TNF-α)水平,分析上述指标之间的差异。结果:牙周炎患者中高血压前期的发病率为42.26%,男性高于女性(P0.01);中、重度牙周炎伴高血压前期的发病率分别为36.64%和42.75%,显著高于轻度牙周炎伴高血压前期的发病率(P0.05或0.01);牙周炎伴高血压前期组的血清hs-CRP、IL-6、TNF-α水平显著高于单纯牙周炎组(P0.05或P0.01);多元逐步回归分析显示,中、重度牙周炎与高血压前期呈独立相关(P0.05),血清hs-CRP、IL-6、TNF-α水平与牙周炎伴高血压前期呈独立相关(P0.05)。结论:牙周炎患者高血压前期的发病率较高;炎性细胞因子与牙周炎伴高血压前期密切相关。
[Abstract]:Objective: to investigate the incidence of prehypertension in patients with periodontitis, and to analyze the relationship between the severity of periodontitis and prehypertension. To explore the role of inflammatory cytokines in periodontitis with prehypertension. Methods: the blood pressure and periodontal examination were measured in 310 patients with periodontitis, and the incidence of prehypertension in periodontitis was investigated. The relationship between severe periodontitis and prehypertension was studied in 43 cases of periodontitis, 40 cases of periodontitis with prehypertension, 38 cases of hypertension. The serum levels of high sensitive C-reactive protein (hs-CRPU), interleukin-6 (IL-6) and tumor necrosis factor TNF- 伪 (TNF- 伪) were measured, and the differences were analyzed. Results: the incidence of prehypertension in patients with periodontitis was 42.26 and that in men was higher than that in women (P 0.01). The incidence of severe periodontitis with hypertension was 36.64% and 42.75, respectively, which was significantly higher than that of mild periodontitis with hypertension (P0.05 or 0.01), and the serum levels of hs-CRPP-IL-6 TNF- 伪 in patients with severe periodontitis with hypertension were significantly higher than those with simple periodontitis (P0.05). Or P0.01; multiple stepwise regression analysis showed that, There was an independent correlation between moderate and severe periodontitis and prehypertension (P 0.05), and an independent correlation between serum hs-CRP (IL-6) TNF- 伪 level and periodontitis associated with hypertension (P 0.05). Conclusion: the incidence of prehypertension is higher in periodontitis patients. Inflammatory cytokines are closely related to periodontitis with prehypertension.
【作者单位】：佛山市口腔医院、佛山科学技术学院附属医院内科;佛山市口腔医院牙周科;
【基金】：广东省佛山市医学科技攻关项目(No:201308074)
【分类号】：R544.1;R781.42

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