不同剂量的右美托咪啶和咪唑安定在口腔种植手术中的镇静效果

发布时间：2018-03-10 19:24

本文选题：右美托咪啶　切入点：咪唑安定　出处：《华西口腔医学杂志》2015年02期 　论文类型：期刊论文

【摘要】：目的比较不同剂量的右美托咪啶与咪唑安定在口腔种植手术患者中的镇静效果。方法选择60例需行口腔种植牙的健康患者,随机分为6组,每组10例。1组(G1)单独使用高剂量咪唑安定;2组(G2)低剂量咪唑安定复合低剂量右美托咪啶;3组(G3)高剂量咪唑安定复合高剂量右美托咪啶;4组(G4)为低剂量咪唑安定复合高剂量右美托咪啶;5组(G5)为高剂量咪唑安定复合低剂量右美托咪啶;6组(G6)单独使用高剂量右美托咪啶。记录各组镇静前、手术中、手术结束时患者血压、心率、血氧饱和度。记录并比较各组局部麻醉(T1)、切开(T2)、备洞(T3)、缝合(T4)时患者Ramsay镇静评分(RSS)以及对T1~T4的记忆情况,离院前进行手术疼痛评分及患者满意度调查。结果 G3组收缩压在T1~T4时均低于G1、G2组(P0.05);G1组收缩压在T3、T4时高于G6组(P0.05)。G3组术中心率低于术前(P0.05)。T1~T4时G1组RSS评分最低;G2组多为2~3分;G3组镇静较深,多例达到5分;G4组以3~4分居多;G5组在T2时开始有部分达到5分;G6组在T1、T2时低于G3、G4、G5组,在T2时接近G4组。各组疼痛评分及麻醉手术满意度比较未见差异。结论联合使用右美托咪啶和咪唑安定镇静优于单独使用,低剂量咪唑安定联合高剂量右美托咪啶镇静效果及程度最满意。
[Abstract]:Objective to compare the sedative effects of dexmetidine and midazolam in oral implant surgery. Methods 60 healthy patients with dental implants were randomly divided into 6 groups. Low dose midazolam combined with low dose dextromidine group 3) High dose midazolam combined with high dose dexmezolidine 4 group (G4) was low dose midazolam complex (n = 10, n = 10, n = 10, n = 10, n = 10) (n = 10, n = 10): high dose midazolam alone (n = 2, n = 2)) low dose midazolam combined with low dose dextromidine (n = 3). High dose of metopromazidime combined with low dose of dexmetidine group 6 (group G5) was treated with high dose of dexmetomidine alone. Before sedation of each group, the dose of dexmetomidine was recorded before sedation. During the operation, blood pressure, heart rate and oxygen saturation were recorded and compared at the end of the operation. The Ramsay sedation score and memory of T1 T4 were recorded and compared during the operation. Results the systolic blood pressure in group G3 was lower than that in group G1 at T1 T4, and that in group G3 was higher than that in group G6 at T3 and T4. The rate of operation center in group G3 was lower than that in group G6 (P0.05. T4). T1T4 was lower in group G1 than that in group G 2 (P 0. 05. T4). The sedation was deep in group G3 with 2 ~ 3 minutes. There were some cases in group G6 with 5 minutes at T2 and lower than that in group G5 at T _ 1 and T _ 2 compared with those in group G _ 3 and group G _ 5, which were separated by 3 / 4 and separated by 3 / 4 / 4 respectively at T _ 2 / T _ 2, respectively, which were lower than those in group G _ (5). There was no difference in pain score and satisfaction of anesthesia operation in group G4 at T2. Conclusion combined use of dexmetidine and midazolam is superior to sedation alone. Low-dose midazolam combined with high-dose dexmetidine had the most satisfactory sedative effect and degree.
【作者单位】：四川省医学科学院四川省人民医院麻醉科;四川省医学科学院四川省人民医院口腔科;
【分类号】：R782.054

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