牙周基础治疗对口腔扁平苔藓伴慢性牙周炎患者外周血MMP-3及IFN-γ水平的影响

发布时间：2018-03-11 04:29

本文选题：口腔扁平苔藓(OLP)　切入点：慢性牙周炎(CP)　出处：《实用口腔医学杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的:观察牙周基础治疗前后口腔扁平苔藓伴慢性牙周炎患者血清中基质金属蛋白酶-3(MMP-3)和干扰素-γ(IFN-γ)浓度的变化。方法:选取60例诊断为伴有牙周炎的糜烂型口腔扁平苔藓患者,随机分为2组,其中实验组30例进行牙周基础治疗联合药物治疗,治疗前后,检测牙周指数PD、AL、BI和PLI。对照组30例采取药物治疗。用ELLSA检测治疗前后2组患者血清中MMP-3及IFN-γ的表达水平,分析各组细胞因子浓度的差异。结果:治疗后实验组牙周指数明显下降(P0.05);2组患者血清中的MMP-3及IFN-γ表达水平与治疗前相比下降(P0.05);经过治疗后,实验组MMP-3及IFN-γ表达水平下降趋势较对照组明显(P0.05)。结论:牙周基础治疗在口腔扁平苔藓治疗中起到了积极作用,可有效降低炎症水平。
[Abstract]:Objective: to observe the changes of serum levels of matrix metalloproteinase-3 (MMP-3) and interferon- 纬 (IFN- 纬) in patients with chronic periodontitis and oral lichen planus before and after basic periodontal treatment. Methods: 60 cases of erosive oral lichen planus with periodontitis were selected. They were randomly divided into two groups: the experimental group (30 cases) received periodontal basic therapy combined with drug therapy before and after treatment. The periodontal index (PDI) and periodontal index (Pi) were measured. 30 patients in the control group were treated with drugs. The levels of MMP-3 and IFN- 纬 in serum of the two groups were detected before and after ELLSA treatment. Results: after treatment, the periodontal index of the experimental group decreased significantly, the expression of MMP-3 and IFN- 纬 in the serum of the patients of the P0.05 group decreased compared with that of the patients before and after the treatment, the expression levels of IFN- 纬 in the serum of the patients in the experimental group were significantly decreased than those before the treatment. The expression of MMP-3 and IFN- 纬 in the experimental group was significantly lower than that in the control group (P 0.05). Conclusion: periodontal basic therapy plays an active role in the treatment of oral lichen planus and can effectively reduce the level of inflammation.
【作者单位】：哈尔滨医科大学附属第二医院口腔牙周黏膜科;
【分类号】：R781.5

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