牙周非手术治疗对重度慢性牙周炎患者龈沟液中MMP-8和TIMP-1水平的影响

发布时间：2018-03-11 07:30

本文选题：口腔　切入点：牙周炎　出处：《福建医科大学学报》2015年06期 　论文类型：期刊论文

【摘要】：目的评价牙周非手术治疗对重度慢性牙周炎患牙龈沟液(GCF)中基质金属蛋白酶-8(MMP-8)及其组织抑制剂-1(TIMP-1)水平的影响。方法选取20颗重度牙周炎患牙,牙周非手术治疗前后检查菌斑指数(PLI)、牙周袋深度(PD)、出血指数(BI)、附着丧失(AL),收集GCF,采用酶联免疫吸附法(ELISA)检测GCF中MMP-8和TIMP-1的含量。结果牙周非手术治疗能显著改善PLI、PD、BI和GCF的量(P0.01)以及AL(P0.05)。GCF中MMP-8和TIMP-1的水平在治疗前后无明显变化;除TIMP-1与治疗后PLI呈正相关关系外(P0.05),MMP-8和TIMP-1与其他临床指标均无显著相关性。结论牙周非手术治疗能有效改善重度慢性牙周炎的临床指标,但不能改变GCF中MMP-8和TIMP-1的水平。
[Abstract]:Objective to evaluate the effect of nonoperative periodontal treatment on the levels of matrix metalloproteinase-8 (MMP-8) and tissue inhibitor (TIMP-1) in GCFs of patients with severe chronic periodontitis. Methods Twenty teeth with severe periodontitis were selected. The plaque index (PLI), the depth of periodontal bag (PDD), the bleeding index (Pi), the appurative loss of alanine (GCF) and the content of MMP-8 and TIMP-1 in GCF were detected by enzyme linked immunosorbent assay (Elisa) before and after non-operative treatment. Results the results showed that the periodontal non-operative treatment could significantly improve the level of MMP-8 and TIMP-1. The levels of MMP-8 and TIMP-1 in AL(P0.05).GCF did not change significantly before and after treatment. There was no significant correlation between MMP-8 and TIMP-1 and other clinical indexes except TIMP-1 and PLI after treatment. Conclusion Non-operative periodontal treatment can effectively improve the clinical indexes of severe chronic periodontitis, but can not change the levels of MMP-8 and TIMP-1 in GCF.
【作者单位】：福建医科大学附属口腔医院牙周科;厦门市口腔医院牙周科;福州市中医院口腔科;南京大学医学院附属口腔医院;
【基金】：福建省卫生系统中青年骨干人才培养项目(2014-ZQNJC-22) 江苏省临床医学科技专项(BL2013002)
【分类号】：R781.42

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