康复新液联合口腔溃疡散治疗复发性阿弗他溃疡的临床观察

发布时间：2018-03-21 14:27

  本文选题：复发性阿弗他溃疡　切入点：康复新液　出处：《中国药房》2016年08期 　论文类型：期刊论文

【摘要】：目的:探讨康复新液联合口腔溃疡散对复发性阿弗他溃疡患者炎性因子及疗效的影响。方法:134例复发性阿弗他溃疡患者采用随机数字表法分为观察组和对照组,各67例。两组患者均给予常规治疗,对照组患者在此基础上加用口腔溃疡散喷洒于口腔溃疡处,q2 h;观察组患者在对照组基础上加用康复新液,每次10 ml,口中含漱5~10 min后缓慢咽下,tid。两组疗程均为7 d。观察两组患者的临床疗效、炎性因子指标、临床症状改善程度及复发情况。结果:观察组患者的总有效率为95.52%,明显高于对照组(82.09%),差异具有统计学意义(P0.05)。观察组患者的肿瘤坏死因子α、白细胞介素(IL)-1、IL-6水平均显著低于对照组,差异具有统计学意义(P0.05);观察组患者的溃疡持续时间显著短于对照组,视觉模拟评分法评分显著低于对照组,差异均具有统计学意义(P0.05)。随访6个月,观察组患者的复发率(11.94%)明显低于对照组(31.34%),差异具有统计学意义(P0.05)。结论:康复新液联合口腔溃疡散有助于降低复发性阿弗他溃疡患者的炎性因子水平,缓解临床症状,提高疗效,降低复发率。
[Abstract]:Objective: to investigate the effect of Kangangxin liquid combined with oral ulcer powder on inflammatory factors and curative effect in patients with recurrent aphthous ulcer. Methods: 134 patients with recurrent aphthous ulcer were randomly divided into two groups: observation group and control group. 67 patients in each group were given routine treatment, and the patients in the control group were sprayed with oral ulcer powder for Q2 h, and the patients in the observation group were treated with new rehabilitation solution on the basis of the control group. 10 ml / time, 5 min after mouth gargling, 10 min after slow swallow tid. The course of treatment in both groups was 7 days. The clinical curative effect and inflammatory factor index were observed in both groups. Results: the total effective rate of the patients in the observation group was 95.522.The total effective rate was significantly higher than that in the control group (P 0.05). The levels of tumor necrosis factor 伪 and interleukin-1 IL-6 in the observation group were significantly lower than those in the control group. The duration of ulcers in the observation group was significantly shorter than that in the control group, and the visual analogue score was significantly lower than that in the control group (P 0.05). The recurrence rate of the patients in the observation group was significantly lower than that in the control group (P 0.05). Conclusion: the level of inflammatory factors in patients with recurrent aphthous ulcer can be reduced, the clinical symptoms can be alleviated and the curative effect improved. Reduce the recurrence rate.
【作者单位】： 华中科技大学同济医学院附属协和医院口腔科;武汉市第一医院口腔科;华中科技大学同济医学院附属协和医院药剂科;
【分类号】：R781.5
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本文编号：1644256