钛芯与骨形成蛋白复合材料修复即刻种植牙槽骨缺陷的评价

发布时间：2018-03-23 12:13

本文选题：骨形态发生蛋白质类　切入点：羟基磷灰石类　出处：《中国组织工程研究》2017年22期

【摘要】：背景:致力于种植牙槽骨缺损修复的实验和临床研究是现代科技发展方向,寻找适合的骨替代材料成为人们研究的热门课题。目的:研究钛芯羟基磷灰石与骨形成蛋白复合材料修复即刻种植后牙槽骨缺陷的效果。方法:将24只新西兰兔随机分为3组,正常组不进行任何处理,实验组、对照组制作股骨大转子区骨缺损模型,实验组于骨缺损处植入种植体及钛芯羟基磷灰石与骨形成蛋白复合材料;对照组植入种植体及钛芯羟基磷灰石材料。植入后4周,检测血CD4~+、CD8~+淋巴细胞比例及NK细胞活性、白细胞介素2水平;植入后16周,采用X射线检测骨密度,组织学观察种植体周围成骨情况。结果与结论:(1)实验组骨密度高于对照组(P0.05);(2)实验组复合材料周围有不同程度的裂解,新生骨组织细胞和基质细胞较为丰富,并且在种植体周围有良好的骨结合接触,内部出现有红染成熟骨组织进入;对照组骨细胞数量、纤维细胞增生少于实验组;(3)实验组CD4~+与CD8~+淋巴细胞比例、NK细胞活性、白细胞介素2水平低于对照组(P0.05);(4)结果表明,钛芯羟基磷灰石与骨形成蛋白复合材料能够有效修复即刻种植后牙槽骨缺陷区域,引导骨细胞生长。
[Abstract]:Background: experimental and clinical research on alveolar bone implant repair is the development direction of modern science and technology. To study the effect of titanium hydroxyapatite and bone morphogenetic protein composite material in repairing alveolar defect after immediate implantation, 24 New Zealand rabbits were randomly divided into 3 groups. The experimental group and the control group made bone defect model in the trochanteric region of femur. The implant and titanium core hydroxyapatite and bone morphogenetic protein composite were implanted in the bone defect in the experimental group. In the control group, implant and titanium core hydroxyapatite were implanted. Blood CD4 ~ + CD8 ~ + lymphocyte ratio, NK cell activity and interleukin-2 level were measured 4 weeks after implantation, and bone mineral density was measured by X-ray at 16 weeks after implantation. Results and conclusion the bone mineral density of the experimental group was higher than that of the control group (P 0.05). In addition, there was good bone binding contact around the implant, red stained mature bone entered inside, and the number of bone cells in the control group was less than that in the experimental group, and the proliferation of fibroblasts was less than that in the experimental group (3) the ratio of CD4 ~ to CD8 ~ lymphocytes in the experimental group was lower than that of the control group. The results showed that the titanium core hydroxyapatite and bone morphogenetic protein composite could effectively repair the defect area of alveolar bone and induce the growth of bone cells.
【作者单位】：河北省人民医院口腔科;河北省人民医院老干部处;
【基金】：2014年度河北省医学科学研究课题计划(ZL20140216)~~
【分类号】：R783.1

【相似文献】