慢性牙周炎与高脂血症相关性的Meta分析

发布时间：2018-04-06 02:10

本文选题：慢性牙周炎　切入点：高脂血症　出处：《华西口腔医学杂志》2017年04期

【摘要】：目的采用系统评价的方法评价慢性牙周炎与高脂血症相关性。方法计算机检索PubMed、Cochrane Library、Embase、中国生物医学文献数据库、相关期刊论文、万方和维普数据库,检索时限从建库到2016年7月,限中、英文,由两位研究者按标准纳入牙周炎与高脂血症相关性的观察性研究论文,进行资料提取及质量评价,采用RevMan 5.3软件进行Meta分析并用GRADE 3.6软件进行证据整体质量等级的评定。结果一共纳入6个病例对照研究和1个队列研究。Meta分析结果显示,慢性牙周炎患者血清中甘油三酯(TG)的浓度明显高于牙周健康组(MD=50.50,95%可信区间=39.57~61.42,P0.000 01),血清总胆固醇(TC)浓度也较牙周健康组明显增(MD=17.54,95%可信区间=10.91~24.18,P0.000 01);并且牙周炎患者血清中TG与TC升高的风险分别是牙周健康者的4.73倍(OR=4.73,95%可信区间=2.74~8.17,P0.000 01)和3.62倍(OR=3.62,95%可信区间=2.18~6.03,P0.000 01);而两组在高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)的统计学差异不大。结论现有证据表明慢性牙周炎与高脂血症是存在相关性的,慢性牙周炎是高脂血症的一个独立危险因素,尤其是对血清中的TC和TG有显著影响
[Abstract]:Objective to evaluate the relationship between chronic periodontitis and hyperlipidemia by systematic evaluation.Methods A computer-based search was conducted for PubMeden Cochrane Library Embase, Chinese Biomedical Literature Database, Chinese Journal Full-text Database, Wanfang and Weip databases. The time limit for retrieval was from the establishment of the database to July 2016.According to the standard, two researchers were included in the observational research papers on the correlation between periodontitis and hyperlipidemia. The data were extracted and the quality was evaluated. The Meta was analyzed by RevMan 5.3 software and the overall quality grade of evidence was evaluated by GRADE 3.6 software.Results A total of 6 case-control studies and 1 cohort study. Meta-analysis showed that,Conclusion there is a correlation between chronic periodontitis and hyperlipidemia. Chronic periodontitis is an independent risk factor for hyperlipidemia, especially TC and TG in serum.
【作者单位】：中南大学湘雅二医院口腔修复科;
【分类号】：R589.2;R781.42

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