幽门螺杆菌感染与复发性口腔溃疡的相关性研究

发布时间：2018-04-12 19:24

本文选题：幽门螺杆菌 + 复发性口腔溃疡　；参考：《中华医院感染学杂志》2014年06期

【摘要】：目的研究幽门螺杆菌(Hp)感染与复发性口腔溃疡(RAU)的相关性,探寻复发性口腔溃疡的发病机制。方法选择2012年1月-2013年1月136例RAU患者作为RAU组,同时选择同期136名健康体检者作为健康组,均采用C-尿素呼气试验(C-UBT)及胃镜进行口腔及胃Hp检测;将RAU组消化道Hp阳性患者根据治疗方法分为观察组与对照组,所有患者均常规抗炎治疗,观察组在常规治疗的基础上给予阿莫西林+雷尼替丁+甲硝唑三联治疗,对两组治疗效果进行比较。结果 RAU组口腔Hp阳性61例、消化道Hp阳性46例,阳性率分别为44.85%、33.82%,健康组口腔Hp阳性20名、消化道Hp阳性19名,阳性率分别为14.71%、13.97%,两组比较差异有统计学意义(P0.05);两组消化道Hp阳性患者,消化道溃疡发生率分别为78.26%与63.16%,差异无统计学意义;RAU组46例消化道Hp阳性患者中观察组23例治疗总有效率82.61%,对照组23例治疗总有效率56.52%,两组比较差异有统计学意义(P0.05)。结论 Hp感染与复发性口腔溃疡有一定的相关性,复发性口腔溃疡患者Hp阳性率高于口腔健康者,抗Hp三联治疗后对口腔溃疡的愈合具有一定影响。
[Abstract]:Objective to study the relationship between Helicobacter pylori (HP) infection and recurrent oral ulcer (Rau), and to explore the pathogenesis of recurrent oral ulcer.Methods from January 2012 to January 2013, 136 patients with RAU were selected as RAU group and 136 healthy persons as control group. All patients were detected by C-UBT and gastroscopy.Patients with HP positive in digestive tract of RAU group were divided into observation group and control group according to the treatment method. All the patients were treated with routine anti-inflammatory therapy. The observation group was treated with amoxicillin ranitidine metronidazole on the basis of routine treatment.The therapeutic effects of the two groups were compared.Results in RAU group, 61 cases were positive for oral HP and 46 cases for HP in digestive tract, the positive rates were 44.85% and 33.82%, respectively. In healthy group, 20 cases were positive for oral HP and 19 cases were positive for HP in digestive tract.The positive rates were 14.71 and 13.97, respectively. The difference between the two groups was statistically significant (P 0.05).The incidence of digestive tract ulcer was 78.26% and 63.16, respectively. There was no significant difference between the two groups in the total effective rate of 82.61 cases in the observation group (23 cases) and in the control group (56.52%). The difference between the two groups was statistically significant (P 0.05).Conclusion HP infection is associated with recurrent oral ulcer. HP positive rate in patients with recurrent oral ulcer is higher than that in healthy oral cavity. Anti-HP triple therapy has a certain effect on healing of oral ulcer.
【作者单位】：杭州市红十字会医院口腔科;
【基金】：浙江省卫生厅研究基金项目(2009A060)
【分类号】：R781.5

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