西帕依固龈液治疗单纯性牙龈炎临床疗效及口臭值的系统评价

发布时间：2018-04-14 10:10

本文选题：西帕依固龈液 + 单纯性牙龈炎　；参考：《世界科学技术-中医药现代化》2014年08期

【摘要】：目的:系统评价西帕依固龈液治疗单纯性牙龈炎的临床疗效及对口臭值的改善。方法:计算机检索CNKI中国知网(总库)(1979-2012)年、维普期刊资源整合服务平台(1989-2013)年、美国图书馆PubMed/MEDLINE相关文献。根据Jadad量表对纳入文献进行质量评价。采用Cochrane协作网提供的RevMan 5.2.0分析软件进行Meta分析。结果:共纳入4项临床随机对照研究,共360例单纯性牙龈炎患者。Meta分析结果显示,西帕依固龈液与生理盐水、西药比较治疗单纯性牙龈炎口臭值(OS)的加权均差(WMD)(95%置信区间)分别为-0.48(-0.81,-0.16)、0.04(-0.15,0.22);西帕依固龈液与生理盐水、西药比较治疗单纯性牙龈炎临床疗效相对危险度(RR)(95%置信区间)分别为1.67(1.29,2.15)、1.22(0.35,4.20)。结论:当前的临床证据显示,西帕依固龈液治疗单纯性牙龈炎疗效优于生理盐水,与西药作用相似,可降低牙龈炎患者口臭值,且无明显副作用,服用方便。由于纳入研究样本量小且质量较低,尚需开展高质量、多中心、大样本的临床随机双盲对照试验加以证实。
[Abstract]:Objective: to evaluate the clinical effect and the improvement of halitosis in the treatment of simple gingivitis with cipayil gingival fluid.Methods: CNKI China Information Network (CNKI) (1979-2012), WIP periodical Resources Integration Service platform (1989-2013), PubMed/MEDLINE related documents in American libraries were searched.The quality of the literature was evaluated according to the Jadad scale.RevMan 5.2.0 analysis software provided by Cochrane cooperation network is used for Meta analysis.Results: a total of 360 patients with simple gingivitis were enrolled in 4 randomized controlled trials.The weighted mean difference (WMD) 95% confidence interval (WMD-95% confidence interval) for comparison of western medicine in treating simple gingivitis was -0.48 ~ (-1) -0.81 ~ (-0.16) ~ (0.04) ~ (0.150.22); the relative risk of clinical efficacy of sipanil in gingivitis was 1.67 / 1.292.2.22 ~ (2) ~ (1.220.22) ~ (0.35) ~ (4.20)), and the relative risk of comparison of western medicine in the treatment of simple gingivitis was 1.67 / 1.292.151.220.35 ~ (5) ~ (4.20) ~ (%).Conclusion: the current clinical evidence shows that the therapeutic effect of cipail gingival fluid on simple gingivitis is better than that of normal saline, similar to that of western medicine, it can reduce the halitosis value of gingivitis patients, and has no obvious side effects, so it is convenient to take.Because the sample size is small and the quality is low, high quality, multi-center, large sample clinical double-blind controlled trial should be carried out.
【作者单位】：新疆医科大学科学技术处;新疆医科大学附属中医医院;
【基金】：国家自然科学基金委地区基金(81060312):没食子鞣质对口腔细菌生物膜及牙体硬组织矿化作用机制研究,负责人:赵今
【分类号】：R781.3

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