口腔鳞癌中LATS2基因mRNA与蛋白表达及其相关性

发布时间：2018-04-15 10:14

本文选题：口腔鳞癌(OSCC) + LATS　；参考：《实用口腔医学杂志》2016年03期

【摘要】：用RT-PCR和Western blot检测57例口腔鳞癌组织及12例正常口腔黏膜组织中LATS2 mRNA和蛋白表达;发现口腔黏膜正常组织中LATS2 mRNA和蛋白的表达率为100%;口腔鳞癌组织中LATS2基因mRNA和蛋白的表达率分别为47.4%(27/57)和42.1%(24/57),二者表达具有明显的相关性(P0.01),均与患者肿瘤的分化程度及淋巴结转移明显相关(P0.05)。
[Abstract]:RT-PCR and Western blot were used to detect the expression of LATS2 mRNA and protein in 57 cases of oral squamous cell carcinoma and 12 cases of normal oral mucosa.It was found that the expression rate of LATS2 mRNA and protein was 100 in normal oral mucosa and 47.427 / 57 in LATS2 in oral squamous cell carcinoma, and 42.1 / 57 in oral squamous cell carcinoma, respectively. There was a significant correlation between the expression of LATS2 mRNA and protein in oral squamous cell carcinoma and the degree of tumor differentiation in patients with oral squamous cell carcinoma (OSCC).And lymph node metastasis were significantly correlated with P0.05.
【作者单位】：郑州大学第四附属医院;
【基金】：河南省教育厅科学技术研究重点项目指导计划(编号:14B320018)
【分类号】：R739.8

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