Ki-67与D2-40在口腔鳞癌颈淋巴的表达差异

发布时间：2018-04-15 15:54

  本文选题：口腔鳞癌 + 淋巴管密度　； 参考：《北京协和医学院》2014年硕士论文

【摘要】：目的： 观察口腔鳞癌中淋巴管生成情况,分析口腔鳞癌的瘤内和瘤周淋巴管密度及肿瘤浸润深度等临床病理指标与肿瘤颈淋巴结转移的相关性。 方法： 采用免疫组化SP法检测69例口腔鳞癌Ki-67、D2-40,分析瘤内和瘤周淋巴管密度,以及肿瘤浸润深度,结合临床病理因素分析其与颈部淋巴结转移的相关性。 结果： 1.总的“热点”平均淋巴管密度为11.2个／HPF。淋巴管密度在牙龈癌瘤内增大与淋巴转移组和非转移组间有明显相关性；与舌癌淋巴结转移之间显著相关(P=-0.011)。 2.高分化口腔癌中Ki-67的阳性表达率瘤内、瘤周之间有显著的表达差异(P0.0001),瘤内较瘤周明显高表达。口腔癌淋巴转移与Ki-67免疫组化阳性表达未发现明显相关性。 3.舌癌、口底癌中肿瘤浸润深度与颈淋巴结转移有显著正相关性。 结论： 1.本研究发现肿瘤的浸润深度与舌癌、口底鳞癌的颈淋巴结转移呈明显正相关；当肿瘤浸润深度≥5mm时,临床中应考虑选择颈淋巴结清扫。 2.在牙龈癌中,肿瘤的瘤内淋巴管密度在有淋巴结转移组和无淋巴结转移组中有显著统计学差异。淋巴管密度及肿瘤浸润深度是舌癌、口底癌发生淋巴转移的重要风险因素。 3.Ki-67对判断牙龈癌分化程度有一定参考价值。
[Abstract]:Objective:To observe the lymphangiogenesis in oral squamous cell carcinoma (OSCC) and to analyze the correlation between lymphatic vessel density and depth of tumor invasion in oral squamous cell carcinoma (OSCC) and cervical lymph node metastasis.Methods:Immunohistochemical SP method was used to detect Ki-67D2-40 in 69 cases of oral squamous cell carcinoma (OSCC). The density of lymphatic vessels in and around the tumor and the depth of tumor invasion were analyzed. The correlation between Ki-67D2-40 and cervical lymph node metastasis was analyzed with clinicopathological factors.Results:1.The mean total "hot spot" lymphatic vessel density was 11.2 / HPF.There was a significant correlation between lymphatic vessel density in gingival carcinomas and lymph node metastasis and tongue cancer lymph node metastasis.2.The positive expression rate of Ki-67 in well-differentiated oral carcinoma was significantly higher than that in the surrounding tumor (P 0.0001).There was no significant correlation between lymphatic metastasis and Ki-67 immunohistochemical expression in oral carcinoma.3.There was a significant positive correlation between the depth of tumor invasion and cervical lymph node metastasis in tongue and floor carcinoma.Conclusion:1.This study found that the depth of tumor invasion was positively correlated with the cervical lymph node metastasis of tongue cancer and squamous cell carcinoma of the floor of mouth, and when the depth of tumor invasion was 鈮，

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