代谢综合征相关线粒体基因单核苷酸多态性与慢性牙周炎的关系

发布时间：2018-04-16 04:35

本文选题：代谢综合征 + 牙周炎　；参考：《北京大学学报(医学版)》2014年02期

【摘要】：目的:检测227名北京市中老年人群的线粒体DNA(mitochondrial DNA,mtDNA)10398位点的单核苷酸多态性(single nucleotide polymorphism,SNP),探讨其与慢性牙周炎严重程度的关系。方法:227名北京市某社区居民于2005年接受了问卷调查、牙周检查和生化检查,以这些个体线粒体基因中特定片段DNA进行PCR扩增、测序,分析mtDNA 10398位点SNP与代谢综合征(metabolic syndrome,MS)及慢性牙周炎严重程度的关系。结果:在MS个体中,mtDNA 10398 G基因型明显高于非MS个体[80(70.2%)vs.34(29.8%),P=0.039],并且10398 G基因型的个体患MS的风险明显高于10398 A基因型(OR=1.77,95%CI=1.02~3.06,P=0.042),但是没有发现该基因SNP与牙周炎的严重程度有明显的相关性。结论:该社区人群mtDNA 10398 A→G SNP和MS有相关性,但与牙周炎的严重程度没有明显关系。
[Abstract]:Objective: to study the single nucleotide polymorphisms (SNPs) at mtDNA10398 of mitochondrial DNA(mitochondrial in 227 middle-aged and elderly population in Beijing, and to investigate the relationship between SNPs and the severity of chronic periodontitis.Methods A total of 227 residents in a community in Beijing were investigated by questionnaire, periodontal examination and biochemical examination in 2005. The specific fragments of mitochondrial gene DNA were amplified by PCR and sequenced.To analyze the relationship between mtDNA 10398 SNP and metabolic syndrome (MS) and the severity of chronic periodontitis.Results: the genotype of mtDNA 10398 G in MS individuals was significantly higher than that in non-MS individuals [80n70.2], and the risk of MS in individuals with genotype 10398 G was significantly higher than that in individuals with genotype 10398 A, OR1.77-95CIN 1.023.06P0.042a, but there was no significant correlation between the SNP gene and the severity of periodontitis.Conclusion: there is a correlation between mtDNA 10398 A G SNP and MS, but there is no significant relationship between the severity of periodontitis and mtDNA 10398 A G SNP.
【作者单位】：北京大学口腔医学院·口腔医院牙周科;北京市高血压联盟研究所人类基因实验室;北京大学口腔医学院·口腔医院第二门诊部;
【基金】：国家自然科学基金(81271148) 国家临床重点专科建设项目资助~~
【分类号】：R781.42

【共引文献】