米诺环素软膏与碘甘油治疗慢性牙周炎的效果观察

发布时间：2018-04-20 00:04

本文选题：慢性牙周炎 + 米诺环素　；参考：《中国生化药物杂志》2014年04期

【摘要】：目的观察对比米诺环素软膏和碘甘油用于治疗慢性牙周炎的效果。方法选取2012年1月~2013年1月间在本院治疗的82例慢性牙周炎患者并随机将他们分为A组和B组,每组41例。2组均给予基础治疗:去除局部刺激,采用龈下刮治及根面平整术清楚软垢、菌斑、牙石,调整咬合创伤与食物嵌塞,用3%的双氧水、洗必泰溶液冲洗牙周袋。A组在基础治疗上加用米诺环素软膏,B组加用碘甘油药物。观察治疗前后2组患者牙周临床指标变化和龈沟液中MMP-8、sICAM-1的变化情况,并评价2种药物的疗效。结果治疗后A组患者有效率100%,明显高于B组患者的92.8%(P0.05)。治疗后2组牙周临床指标都得到明显缓解,龈沟液中MMP-8、sICAM含量均明显降低(P0.05),且A组较B组降低更明显,差异有统计学意义(P0.05)。结论米诺环素和碘甘油均能有效治疗慢性牙周炎,但米诺环素软膏临床效果更好。
[Abstract]:Objective To observe and compare the effect of minocycline ointment and Iodine Glycerol in the treatment of chronic periodontitis. Methods 82 patients with chronic periodontitis were randomly divided into group A and group B in January 2012 ~2013 years and January, and each group of 41 cases of.2 were treated with basic treatment: removal of local stimulation, subgingival scraping and root surface leveling. Chu soft scale, plaque, tooth stone, adjust occlusal trauma and food impaction, use 3% hydrogen peroxide and chlorhexidine solution to rinse the periodontal pocket.A group with minocycline ointment, group B plus Iodine Glycerol, observe the changes of periodontal clinical indexes and the changes of MMP-8 and sICAM-1 in gingival crevicular fluid in the 2 groups before and after treatment, and evaluate the 2 kinds of drugs. Results after treatment, the effective rate of the A group was 100%, obviously higher than that of the B group (P0.05). The periodontal clinical indexes of the 2 groups were obviously relieved, the content of MMP-8 and sICAM in the gingival crevicular fluid decreased significantly (P0.05), and the decrease of A group was more obvious than that of the B group (P0.05). Conclusion minocycline and Iodine Glycerol can be effectively treated. Chronic periodontitis, but minocycline ointment has better clinical effect.

【作者单位】：白城医学高等专科学校;
【基金】：吉林省科技厅资助课题(20030424-03)
【分类号】：R781.42

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