明胶-聚苯胺导电水凝胶的制备与研究

发布时间：2018-04-20 03:20

本文选题：导电水凝胶 + 明胶　；参考：《南京医科大学学报(自然科学版)》2017年09期

【摘要】：目的 :明胶-聚苯胺接枝共聚物(gelatin-graft-polyaniline,GP)导电水凝胶的制备和性能研究。方法:采用直接掺杂法制作GP,使用樟脑磺酸(camphor sulfonic acid,CSA)作为掺杂剂。GP溶于水形成导电水凝胶(gelatin-graft-polyaniline hydrogel,GPH),以1-(3-二甲氨基丙基)-3-乙基碳二亚胺盐酸盐[1-(3-dimethylaminoproply)-3-ethylcarbodiimide,EDC]进行交联。对制备的GP和GPH的形态结构、生物相容性、溶解性、溶胀比和导电性能进行观察研究。结果:GPH导电性能良好(1×10~(-4)~1×10~(-3)S/cm),并随着苯胺含量的增大而增大。但当苯胺的量提高到一定程度,通过明胶共聚获得的GPH溶解性大大降低,同时溶胀比增加。结论:GPH是一种新型的可降解生物材料,具有良好的导电性能,作为支架在组织工程修复中有巨大的应用前景。
[Abstract]:Aim: to study the preparation and properties of gelatin-graft-polyaniline GP-based conductive hydrogel. Methods: GPs were prepared by direct doping method, and then crosslinked with 1-3-dimethylaminoproplyne-3-ethylcarbodiimide-carbodiimide (1-3-dimethylaminoproplyne-3-ethylcarbodiimide-EDC). GP was dissolved in water to form gelatin-graft-polyaniline hydrogelatin (GPHN), and 1-dimethylaminopropyl-3-ethylcarbodiimide (EDC) was crosslinked with 1-dimethylaminoproply- 3-ethylcarbodiimide-carbodiimide (1-3-dimethylaminoproply-3-ethylcarbodiimide-EDC). The morphology, biocompatibility, solubility, swelling ratio and conductivity of GP and GPH were studied. Results the conductivity of 1 脳 10 ~ (-4) C ~ (-1) 脳 10 ~ (10) C ~ (-3) S / cm ~ (-1) S / cm ~ (-1) is good, and it increases with the increase of aniline content. However, when the amount of aniline increased to a certain extent, the solubility of GPH obtained by gelatin copolymerization decreased greatly, and the swelling ratio increased. Conclusion as a new biodegradable biomaterial, the weight GPH has good electrical conductivity and has great application prospect as scaffold in tissue engineering repair.
【作者单位】：南京医科大学第一附属医院口腔科;
【基金】：国家自然科学基金(81670967) 江苏省卫生厅面上项目(H201504) 江苏省“六大人才高峰”第八批高层次人才项目(WSW-021)
【分类号】：R318.08;R782

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