口腔鳞状细胞癌患者血清中巨噬细胞炎性蛋白-1α的表达及意义

发布时间：2018-04-27 16:07

  本文选题：巨噬细胞炎性蛋白-α + 口腔鳞状细胞癌　； 参考：《临床检验杂志》2014年11期

【摘要】：目的探讨巨噬细胞炎性蛋白-1α(macrophage inflammatory protein-1α,MIP-1α)在口腔鳞状细胞癌(OSCC)患者血清中的表达及意义。方法收集29例健康人、21例经病理证实为白斑的患者和60例OSCC患者的血清,用ELISA检测MIP-1α的表达水平,分析其与临床、病理参数的关系。结果白斑患者和OSCC患者血清中MIP-1α的水平分别为170.6(145.0,252.0)pg/m L和118.2(60.48,230.0)pg/m L,较健康人82.54(52.26,105.8)pg/m L显著上升,差异有统计学意义(U=53.0,P0.01;U=575.5,P=0.010 1)。TNM分期Ⅲ~Ⅳ期OSCC患者血清中MIP-1α水平高于Ⅰ~Ⅱ期(P0.05),肿瘤直径4 cm的患者血清中MIP-1α水平高于肿瘤直径≤4 cm的患者(P0.05)。MIP-1α的表达与外周血中单核细胞比例呈正相关(P0.05),与外周血中性粒细胞比例呈负相关(P0.05)。结论 OSCC患者血清MIP-1α的表达升高,提示其可能在肿瘤发生、发展中发挥一定的作用。
[Abstract]:Objective to investigate the expression and significance of macrophage inflammatory protein 1 伪 macrophage inflammatory protein-1 伪 MIP-1 伪 in patients with oral squamous cell carcinoma (OSCC). Methods the serum samples of 21 patients with leukoplakia confirmed by pathology and 60 patients with OSCC were collected from 29 healthy people. The expression of MIP-1 伪 was detected by ELISA, and the relationship between the expression of MIP-1 伪 and clinical and pathological parameters was analyzed. Results the serum levels of MIP-1 伪 in patients with leukoplakia and OSCC were 170.6(145.0252.0)pg/m L and 118.2(60.48230.0)pg/m L, respectively, which were significantly higher than those in healthy controls. The serum MIP-1 伪 level in patients with OSCC in stage 鈪，

本文编号：1811399