白细胞介素10基因型与墨玉县维吾尔族成人慢性牙周炎易感性相关研究

发布时间：2018-04-29 13:48

本文选题：白细胞介素10 + 慢性牙周炎　；参考：《新疆医科大学》2017年硕士论文

【摘要】：目的:探讨白细胞介素10-597(C/A)位点单核苷酸多态性与新疆墨玉县维吾尔族成人慢性牙周炎之间相关性,为该地区维吾尔族成人慢性牙周炎易感性的预测和防治提供理论依据。方法:自我团队前期所建立的新疆墨玉地区慢性牙周炎生物样本库中,根据纳入和排除标准,电脑随机抽取每组100个,共300个颊粘膜试子样本,实验分为健康对照组、轻度慢性牙周炎组、中重度慢性牙周炎组。采用四引物等位基因特异性扩增法检测受试者IL-10-597位点基因型和等位基因的分布,采通过卡方检验、有序多分类Logistic回归等方法进行统计学分析,以探讨IL-10597(C/A)位点与维吾尔族成人慢性牙周炎之间相关性。结果:卡方检验IL-10-597AA、AC和CC基因型及A、C等位基因频率在健康对照组、轻度慢性牙周炎组、中重度慢性牙周炎组组间分布均无统计学意义(P=0.814,P=0,640)。有序多分类Logistic回归分析结果显示,IL-10-597基因位点中任何一种基因型都不是慢性炎牙周炎的易感因素(AA基因型OR=0.78,95%CI:0.41-1.49,P=0.460;AC基因型OR=0.85,95%CI:0.50-1.47,P=0.569)结论:IL-10-597(C/A)位点单核苷酸多态性与新疆墨玉县维吾尔族成人慢性牙周炎发病风险无相关性。
[Abstract]:Objective: To investigate the correlation between the single nucleotide polymorphisms of interleukin 10-597 (C/A) loci and chronic periodontitis in Uygur adults in Moyu County, Xinjiang, and to provide a theoretical basis for the prediction and prevention of the susceptibility to chronic periodontitis in Uygur adults. Method: chronic periodontitis in Xinjiang Moyu area, which was established in the early period of self team. In the sample library, according to the inclusion and exclusion criteria, 100 samples of 300 buccal mucosa specimens were randomly selected by computer. The experiment was divided into healthy control group, mild chronic periodontitis group and moderate and severe chronic periodontitis group. Four primer alleles specific amplification was used to detect the distribution of genotypes and alleles of IL-10-597 loci in the subjects. The correlation between IL-10597 (C/A) loci and Uygur adult chronic periodontitis was analyzed by chi square test and sequential multiple classification Logistic regression. Results: Chi square test the frequency of IL-10-597AA, AC and CC genotypes, A, C alleles in healthy control group, mild chronic periodontitis group, moderate and severe chronic periodontitis The distribution of the groups was not statistically significant (P=0.814, P=0640). The results of sequential multiple classification Logistic regression analysis showed that any genotype in the IL-10-597 loci was not a susceptible factor for chronic inflammatory periodontitis (AA genotype OR=0.78,95%CI:0.41-1.49, P=0.460; AC genotype OR=0.85,95%CI:0.50-1.47, P=0.569): IL-10-597 (C/A) Single nucleotide polymorphisms in loci were not associated with the risk of chronic periodontitis in Uygur adults in Moyu County, Xinjiang.

【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R781.4

【参考文献】