不同剂量尼古丁对大鼠正畸牙移动过程中牙周组织前列腺素E2表达及破骨细胞水平的影响

发布时间：2018-04-30 10:22

本文选题：尼古丁 + 正畸　；参考：《中国老年学杂志》2017年11期

【摘要】：目的探讨不同剂量尼古丁对大鼠正畸牙移动过程中牙周组织前列腺素(PG)E2表达及破骨细胞水平的影响。方法 160只SPF级SD大鼠按照随机数字表法分为对照组、实验1组、实验2组及实验3组,每组40只,分别给予0.9%氯化钠溶液,0.50、0.75、1.00 mg/kg尼古丁酒石酸盐腹腔注射;比较4组大鼠加力后1、3,5、7、14 d牙周组织PGE2表达及破骨细胞计数水平。结果 4组大鼠牙周组织中PGE2表达水平及破骨细胞计数随加力时间延长而逐渐上升,且在加力后5 d达到最大,随后又下降,差异均有统计学意义(均P0.05);4组加力后不同时间PGE2表达水平及破骨细胞计数组间比较差异均有统计学意义(P0.05),实验3组实验2组实验1组对照组,组间两两比较差异均有统计学意义(P0.05)。结论尼古丁会导致大鼠正畸牙移动过程中牙周组织PGE2表达和破骨细胞形成水平上升,且随剂量增加上升更明显,故在正畸过程中应建议患者戒烟,并有效控制牙周炎症。
[Abstract]:Objective to investigate the effects of different doses of nicotine on the expression of prostaglandin PGE _ 2 and osteoclast in periodontal tissue during orthodontic tooth movement in rats. Methods one hundred and sixty SPF SD rats were randomly divided into control group (n = 40), experimental group 1 (n = 40), experimental group 2 (n = 40) and experimental group 3 (n = 40). The expression of PGE2 and the count of osteoclasts in periodontal tissues of rats in 4 groups were compared on the 14th day after treatment. Results the expression level of PGE2 and the osteoclast count in periodontal tissues of the four groups increased gradually with the extension of the stress time, and reached the maximum at the 5th day after the treatment, and then decreased. There were significant differences in PGE2 expression and osteoclast count between the four groups (P 0.05), and there were significant differences in the levels of PGE2 expression and osteoclast count among the four groups (P 0.05), and the difference was significant in the experimental group 2 and the control group 1, respectively, and there was no significant difference in the expression of PGE2 and osteoclast count between the four groups. The differences between two groups were statistically significant (P 0.05). Conclusion nicotine can lead to the increase of PGE2 expression and osteoclast formation in periodontal tissue during orthodontic tooth movement, and it is more obvious with the increase of dosage. Therefore, patients should give up smoking and control periodontitis effectively during orthodontic tooth movement.
【作者单位】：福建医科大学附属泉州第一医院口腔科;泉州医学高等专科学校口腔医学系基础教研室;
【分类号】：R783.5

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