腮腺非皮脂腺淋巴腺瘤2例并文献复习

发布时间：2018-04-30 12:53

本文选题：腮腺肿瘤 + 非皮脂腺淋巴腺瘤　；参考：《临床与实验病理学杂志》2014年12期

【摘要】：目的探讨非皮脂腺淋巴腺瘤(nonsebaceous lymphadenoma,NSL)的临床病理学特征、诊断及鉴别诊断。方法分析2例NSL的临床病理学特征、组织学形态及免疫表型并复习相关文献。结果 2例NSL均为成年女性。镜检:肿瘤主要由上皮成分及间质增生的淋巴组织混合形成,与周围腮腺组织界限清楚,由纤维结缔组织分隔,间质内可见增生的淋巴滤泡。上皮成分可由囊腔、实性岛状、梁状或腺管样结构组成,其中囊腔及腺管样结构由两种细胞成分构成,腔面细胞及外层细胞,囊腔内含伊红不定形物及偶见的泡沫细胞,上皮细胞无皮脂腺分化,形态温和,无非典型性,未见核分裂象。其中1例见完整的纤维被膜包绕整个肿瘤,被膜下见窦结构。免疫表型:上皮细胞CK(AE1/AE3)和CK7阳性,囊腔、腺管样结构的外层细胞p63、CK34βE12和CK5/6阳性。结论 NSL是一种罕见的涎腺良性肿瘤,位于淋巴结内的病变报道较少,组织学结构的多样性使其易与一些涎腺病变相混淆,与一些恶性肿瘤的鉴别尤为重要。
[Abstract]:Objective to investigate the clinicopathological features, diagnosis and differential diagnosis of nonsebaceous lymphoid adenoma (NSL). Methods the clinicopathological features, histomorphology and immunophenotype of 2 cases of NSL were analyzed and the related literatures were reviewed. Results two cases of NSL were all adult female. Microscopic examination: the tumor was mainly composed of epithelial components and lymphoid tissue of interstitial hyperplasia. The boundary between tumor and surrounding parotid tissue was clear, separated by fibrous connective tissue, and hyperplastic lymphoid follicles could be seen in the interstitial tissue. The epithelial component may be composed of a cystic cavity, a solid island, a beam or glandular tubular structure, in which the cystic cavity and glandular tubular structure consist of two cell components, the cavity surface cells and the outer cells, and the vesicle contains eosin amorphous substances and occasional foam cells. The epithelial cells had no sebaceous differentiation, mild morphology and no mitotic appearance. In one case, the whole tumor was covered with a complete fibrous membrane, and the sinus structure was found in the submembrane. Immunophenotype: CK1 / AE3) and CK7 were positive in epithelial cells, and p63 CK34 尾 E12 and CK5/6 were positive in the outer cells of cystic cavity and glandular tubules. Conclusion NSL is a rare benign tumor of salivary gland. The pathological changes located in lymph nodes are rarely reported. The diversity of histological structure makes it easy to be confused with some salivary gland lesions, and it is particularly important to differentiate from some malignant tumors.
【作者单位】：蚌埠医学院第一附属医院病理科;
【分类号】：R739.8

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