舌鳞状细胞癌中EphA7的表达及其与患者病理参数和预后的相关分析

发布时间：2018-05-02 10:55

本文选题：舌鳞状细胞癌 + EphA　；参考：《上海口腔医学》2014年05期

【摘要】：目的:检测舌鳞状细胞癌(tongue squamous cell carcinoma,TSCC)中EphA7的表达,分析其表达水平与TSCC患者临床病理参数及预后的相关性。方法:应用免疫组织化学方法检测54例TSCC及配对癌旁正常组织中EphA7的表达水平,结合随访数据,分析EphA7表达水平与肿瘤病理参数、总体及无瘤生存期的关系。下调SCC9细胞系EphA7的表达水平,检测肿瘤细胞的侵袭、转移能力。采用SPSS17.0软件包进行配对资料t检验和生存分析。结果:所有TSCC组织中均发现EphA7阳性表达,EphA7高表达与不伴淋巴结转移(P0.05)、无血管浸润(P0.05)、致密基质细胞炎症反应(P0.01)以及女性(P0.05)密切相关;与EphA7低表达患者相比,EphA7高表达组表现出更长的总生存期及无瘤生存期(P0.05)。下调EphA7表达的SCC9细胞侵袭、转移能力显著增高(P0.05)。结论:EphA7参与肿瘤恶性进程,影响患者预后,有可能作为TSCC潜在的治疗靶点。
[Abstract]:Objective: to detect the expression of EphA7 in tongue squamous cell carcinoma (TSCC) and to analyze the correlation between the expression of EphA7 and the clinicopathological parameters and prognosis of patients with TSCC. Methods: immunohistochemical method was used to detect the expression of EphA7 in 54 cases of TSCC and matched adjacent normal tissues. The relationship between the expression of EphA7 and tumor pathological parameters, total survival and tumor-free survival was analyzed with follow-up data. The expression of EphA7 in SCC9 cell line was down-regulated and the ability of invasion and metastasis of tumor cells was detected. SPSS17.0 software package was used for t test and survival analysis of paired data. Results: it was found that the high expression of EphA7 in all TSCC tissues was closely related to P0.05 without lymph node metastasis, P0.05 without vascular invasion, P0.01 (inflammatory response of dense stromal cells) and P0.05 (in female). Compared with the patients with low expression of EphA7, the patients with high EphA7 expression had a longer total survival time and a longer tumor-free survival time (P 0.05). The invasion and metastasis ability of SCC9 cells down-regulated EphA7 expression were significantly increased (P 0.05). Conclusion: EphA7 may be a potential therapeutic target for TSCC because of its involvement in malignant progression and prognosis.
【作者单位】：大连医科大学附属第二医院肿瘤科;大连大学口腔医学院;大连医科大学口腔医学院;大连医科大学附属第一医院口腔科;
【基金】：国家自然科学基金(81371161)~~
【分类号】：R739.86

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