牙周炎伴高血压患者牙周临床指标和血清抗心磷脂抗体水平的分析

发布时间：2018-05-07 12:54

本文选题：牙周炎 + 原发性高血压　；参考：《牙体牙髓牙周病学杂志》2014年04期

【摘要】：目的:探讨中、重度慢性牙周炎与原发性高血压之间的关系。方法:纳入慢性牙周炎伴原发性高血压的患者32例,单纯中、重度慢性牙周炎患者38例,健康对照者34例;记录各受试者的菌斑指数(PLI)、探诊深度(PD)、附着丧失(AL)、出血指数(BI)等牙周临床指标后,抽取空腹静脉血并分离血清,采用定量夹心ELISA法检测血清中抗心磷脂抗体IgG(ACA-IgG)、IgM(ACA-IgM)的含量。结果:3组患者中PD、AL、BI各项牙周临床指标以及血清ACA-IgG水平均以慢性牙周炎并发高血压组最高,单纯慢性牙周炎组次之,健康对照组最低,3组间两两相比P0.05;而血清ACA-IgM水平3组间均无显著性差异(P0.05);ACA-IgG水平与PLI、PD、AL、BI均呈显著正相关,r值分别为0.419、0.339、0.661、0.472(P0.05)。结论:高血压可以加重牙周炎患者的牙周破坏程度,而慢性牙周炎可导致高血压患者血清ACA-IgG升高。
[Abstract]:Objective: to investigate the relationship between moderate and severe chronic periodontitis and essential hypertension. Methods: 32 patients with chronic periodontitis associated with essential hypertension, 38 patients with moderate and severe chronic periodontitis and 34 healthy controls were included. After recording the periodontal clinical indexes such as plaque index (PLI), probing depth (PD), attachment loss (ALD) and bleeding index (BI), fasting venous blood was collected and serum was isolated. The serum level of IgGG ABA-IgMACA-IgM was determined by quantitative sandwich ELISA method. Results among the three groups, the clinical indexes and serum ACA-IgG levels were the highest in the chronic periodontitis complicated with hypertension group, followed by the simple chronic periodontitis group. There was no significant difference in serum ACA-IgM level between the three groups. There was a significant positive correlation between the serum ACA-IgM level and the level of ACA-IgM in the control group (P < 0.05). The positive correlation between the serum level of ACA IgG and the level of ACA-IgM in the control group was 0.419 ~ (0.339) ~ 0.661n ~ 0.472P _ (0.05), respectively.The results showed that there was a significant positive correlation between the serum ACA-IgM level of the three groups and the serum level of P0.05 (P _ (0.05). Conclusion: hypertension can aggravate the degree of periodontal destruction in patients with periodontitis, while chronic periodontitis can lead to the increase of serum ACA-IgG in patients with hypertension.
【作者单位】：吉林大学口腔医院牙周病科;
【基金】：吉林大学交叉学科基本科研业务经费资助课题(450060445270) 吉林省长春市社会发展科技计划项目资助课题(12SF82)
【分类号】：R781.4

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