布洛芬联合派丽奥对慢性牙周炎龈沟液中细胞因子的影响及抗氧化作用

发布时间：2018-05-07 18:17

本文选题：布洛芬 + 派丽奥　；参考：《现代预防医学》2014年06期

【摘要】：目的探讨布洛芬联合派丽奥对慢性牙周炎疗效及龈沟液中细胞因子的影响和抗氧化作用。方法采用随机对照试验,2组行龈下刮治及根面平整基础上,治疗组给予派丽奥-布洛芬缓释凝胶注入牙周袋内,溢出即可,1次/周,对照组派丽奥注入牙周袋内,1周/次。1周为1个疗程,共4个疗程。治疗后比较治疗效果和龈沟液中细胞因子的变化及抗氧化作用。结果治疗组和对照组的有效率分别为82.1%和65.5%,治疗组疗效明显优于对照组(P0.05)。治疗前,2组牙周指标、细胞因子、氧化应激指标相比,差异均无统计学意义(P0.05)。第5周时,2组的龈沟出血指数(SBI)、牙周袋深度(PD)、菌斑指数(PLI)、附着水平(AL)、白细胞介素(IL)-1β、IL-6、IL-8、肿瘤坏死因子(TNF)-α、超敏C反应蛋白(hs-CRP)、丙二醛(MDA)、一氧化氮(NO)与治疗前相比均明显降低(P0.05或P0.01),超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)明显升高(P0.05或P0.01),治疗后,治疗组的各指标的变化幅度明显高于对照组(P0.05)。结论布洛芬联合派丽奥对慢性牙周炎疗效明显,能较好地降低炎症水平,减少自由基的发生,有助于牙周组织的重建和恢复。
[Abstract]:Objective to investigate the effect of ibuprofen combined with pyridol on chronic periodontitis and the effects of cytokines in gingival crevicular fluid. Methods on the basis of subgingival curettage and root surface leveling, the treatment group was injected with pereo-ibuprofen sustained-release gel into the periodontal bag. In the control group, Perilla was injected into the periodontal bag for 1 week or 1. 1 week as a course of treatment, with a total of 4 courses. After treatment, the effects of treatment and changes of cytokines in gingival crevicular fluid and anti-oxidation were compared. Results the effective rates of the treatment group and the control group were 82.1% and 65.5% respectively. The curative effect of the treatment group was better than that of the control group (P 0.05). There was no significant difference in periodontal indexes, cytokines and oxidative stress indexes between the two groups before treatment (P 0.05). At the 5th week, the gingival crevicular bleeding index (SBI), periodontal pocket depth (PDD), plaque index (PLI), adhesion level (ALL), interleukin (IL)-1 尾 -tir IL-6 (IL-8), tumor necrosis factor (TNF- 伪), hypersensitive C-reactive protein (hs-CRP), malondialdehyde (MDA), nitric oxide (no) in both groups were significantly decreased compared with those before treatment. (P 0.05 or P 0.01), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) increased significantly (P 0.05 or P 0.01). The change range of each index in the treatment group was higher than that in the control group (P 0.05). Conclusion Ibuprofen combined with Pelio is effective in the treatment of chronic periodontitis, which can reduce the level of inflammation and free radical, and is helpful to the reconstruction and restoration of periodontal tissue.
【作者单位】：漯河医学高等专科学校第三附属医院;
【分类号】：R781.42

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