味觉受体信号转导机制及对微生物的调控

发布时间：2018-05-28 00:36

本文选题：味觉受体 + 微生物　；参考：《华西口腔医学杂志》2017年05期

【摘要】：口腔味蕾细胞中的味觉受体有助于机体鉴别营养物质和有害物质,对哺乳动物的生存具有重要意义。近年来发现,味觉受体及其下游信号转导通路还在呼吸道、大脑、胃肠道等多种组织细胞中表达。表达味觉受体的细胞统称为化学感官细胞,在抵抗微生物感染、调节营养吸收、维持内环境稳态中发挥重要作用。目前已发现多种组织细胞中的味觉受体可识别细菌等微生物,介导宿主免疫应答反应,在感染性疾病发生发展过程中起到重要作用。本文就味觉受体的信号转导机制及其对微生物的调控作用进行综述。
[Abstract]:The taste receptors in oral taste bud cells are helpful to distinguish nutrients from harmful substances and play an important role in the survival of mammals. In recent years, it has been found that taste receptors and their downstream signal transduction pathways are still expressed in respiratory tract, brain, gastrointestinal tract and other tissues and cells. The cells expressing taste receptors are called chemosensory cells, which play an important role in resisting microbial infection, regulating nutrient absorption and maintaining homeostasis of the internal environment. At present, it has been found that taste receptors in various tissue cells can recognize bacteria and mediate host immune response, which play an important role in the occurrence and development of infectious diseases. This review reviews the signal transduction mechanisms of taste receptors and their regulatory effects on microorganisms.
【作者单位】：口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院牙体牙髓病科;
【基金】：国家自然科学基金(81670978,81600874) 四川大学优秀青年学者科研基金(2015SCU04A16)~~
【分类号】：R78

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