C-Met蛋白与HGF蛋白在舌鳞癌细胞中的表达及临床意义

发布时间：2018-05-28 02:11

本文选题：舌鳞癌 + C-Met　；参考：《西安交通大学学报(医学版)》2015年02期

【摘要】：目的探讨C-Met蛋白与肝细胞生长因子(HGF)蛋白在舌鳞癌细胞中的表达及临床意义。方法选取2011年6月至2013年5月我院口腔科收治的舌鳞癌患者46例作为实验组,另取同期在我院进行良性肿瘤切除患者27例作为对照组,正常组织为正常组,均进行免疫组化测定C-Met蛋白及HGF蛋白的表达。结果实验组中C-Met的阴性表达率为21.7%(10/46),弱阳性表达率为26.1%(12/46),强阳性表达率52.2%(24/46);对照组的阴性表达率为77.8%(21/27),弱阳性表达率为15.8%(5/27),强阳性表达率为3.7%(1/27),两组比较差异具有统计学意义(P0.001)。实验组中HGF蛋白的阴性表达率为17.4%(8/46),弱阳性表达率为58.7%(27/46),强阳性表达率23.9%(11/46);对照组阴性表达率为63.0%(17/27),弱阳性表达率为37.0%(10/27),强阳性表达率为0.0%(0/27),两组比较差异具有统计学意义(P0.001)。C-Met蛋白的表达与淋巴结转移比较,差异具有统计学意义(P0.05);HGF蛋白的表达与病理分级、淋巴结转移等比较,差异具有统计学意义(P0.05)。结论 C-Met蛋白及HGF蛋白在舌鳞癌细胞中有显著性表达,且与舌鳞癌的发生、发展有密切关系。
[Abstract]:Objective to investigate the expression and clinical significance of C-Met protein and HGF protein in tongue squamous cell carcinoma cells. Methods from June 2011 to May 2013, 46 patients with squamous cell carcinoma of tongue were selected as experimental group, 27 patients with benign tumor resected in our hospital as control group and normal tissue as normal group. The expression of C-Met protein and HGF protein were detected by immunohistochemistry. Results in the experimental group, the negative expression rate of C-Met was 21.710 / 46%, the weak positive rate was 26.1g / 12 / 46, the strong positive rate was 52.2% / 46%, the negative expression rate of the control group was 77.8% 21 / 27%, the weak positive rate was 15.810% / 27%, and the strong positive rate was 3.771 / 27%. The difference between the two groups was statistically significant (P 0.001). In the experimental group, the negative expression rate of HGF protein was 17.4% / 46%, the weak positive rate was 58.7% / 46%, and the strong positive rate was 23.9% / 46%; the negative expression rate of the control group was 63.0% 17 / 27%, the weak positive rate was 37.0% / 2727%, and the strong positive rate was 0.00 / 2727%. The difference between the two groups was statistically significant (P 0.001N. C-Met). Protein expression was compared with lymph node metastasis. The difference was statistically significant in the expression of HGF, pathological grade, lymph node metastasis and so on. The difference was statistically significant. Conclusion C-Met protein and HGF protein are significantly expressed in tongue squamous cell carcinoma cells, and are closely related to the occurrence and development of tongue squamous cell carcinoma.
【作者单位】：南华大学附属第一医院口腔科;
【基金】：湖南省教育厅支持项目(No.09C842)~~
【分类号】：R739.86

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