新疆不同民族舌体鳞癌预后因素及不同治疗模式疗效分析

发布时间：2018-05-30 14:38

  本文选题：舌癌 + 鳞癌　； 参考：《新疆医科大学》2014年硕士论文

【摘要】：目的：探讨影响新疆不同民族舌体鳞状细胞癌患者预后的临床病理因素及不同治疗模式的治疗效果。方法：选择2003年1月至2011年12月期间在新疆医科大学第一附属医院首治的经病理确诊且随访资料完整的舌体鳞癌病例共132例,应用Kaplan-Meier法行临床病理因素单因素分析及计算单纯手术(S)、单纯放疗(R)、手术+放疗(S+R)、手术+化疗(S+C)、放疗+化疗(R+C)、手术+放疗+化疗(S+R+C)各组治疗后累计生存率,组间差异采用log-rank检验。Cox回归行多因素分析确立影响预后的独立因素及独立治疗模式。结果；132例舌体鳞癌患者的平均生存时间为75.65个月,中位生存期为80.00个月,3年和、5年生存率分别为72.7%、59.8%。单因素分析显示：Ⅰ-Ⅱ期S、R、S+R、S+C、S+R+C各组患者的3年生存率分别为85.7%、66.7%、96.8%、100%、81.8%,P=0.018。Ⅲ-Ⅳ期S、R、S+R、S+C、 R+C、S+R+C各组患者的3年生存率分别为37.5%、14.3%、92.3%、40.0%、14.3%66.7%,P=0.000。多因素分析显示影响预后的独立因素包括：病理分级、原发灶手术、局部复发、TNM分期和放疗,同时手术+放疗、手术+放疗+化疗是影响预后的独立因素。结论：影响预后的独立因素为病理分级、原发灶手术、局部复发TNM分期和放疗。原发灶的彻底手术,合理的颈部淋巴结清扫及降低局部复发能改善舌体鳞癌患者的预后。Ⅰ-Ⅱ期行手术治疗或者手术为主的综合治疗疗效较好,Ⅲ-Ⅳ期行以手术为主的综合治疗预后较好,其中手术+放疗、手术+放疗+化疗是较好的治疗模式,对于中晚期病例行单纯放疗、放疗+化疗预后差。
[Abstract]:Objective: to investigate the clinicopathological factors affecting the prognosis of tongue squamous cell carcinoma (SCC) patients from different nationalities in Xinjiang. Methods: a total of 132 cases of tongue squamous cell carcinoma diagnosed by pathology and followed up from January 2003 to December 2011 in the first affiliated Hospital of Xinjiang Medical University were selected. Kaplan-Meier method was used to analyze the clinicopathological factors and calculate the cumulative survival rate of each group. Multivariate analysis was performed by log-rank test. Cox regression analysis was used to determine the independent prognostic factors and the independent treatment model. Results the average survival time of 132 patients with tongue squamous cell carcinoma was 75.65 months, the median survival time was 80.00months, the 3-year and 5-year survival rates were 72.7% and 59.8 months, respectively. The results of univariate analysis showed that the 3-year survival rate of patients with stage 鈪，

本文编号：1955655