微小RNA在骨分化过程中的作用机制

发布时间：2018-06-05 16:29

本文选题：微小RNA + 骨分化　；参考：《国际口腔医学杂志》2017年01期

【摘要】：在口腔种植治疗过程中常常会遇到骨量不足的问题,植入骨替代材料是目前临床上最主要的重建骨缺损方法之一,因此骨替代材料的成骨性能及其分子机制成为了研究热点。微小RNA(mi RNA)是一种短链非编码RNA,通过转录后调控细胞分化、增殖、程序性死亡等病理生理过程。mi RNA可影响成骨相关因子的表达和激活成骨相关信号转导通路中的信号转导,从而对骨组织动态改建过程进行调控。本文就mi RNA与成骨细胞特异性转录因子、核心结合因子-α1基因、Smad基因、转化生长因子-β诱导因子,与骨形态发生蛋白信号转导通路、无翅型小鼠乳房肿瘤病毒整合位点家族信号转导通路、促丝裂原激活蛋白激酶信号转导通路、成脂信号转导通路以及mi RNA与口腔相关材料和mi RNA在骨缺损修复中的应用研究进展作一综述。
[Abstract]:The problem of insufficient bone mass is often encountered in the process of oral implant therapy. Bone substitute material is one of the most important methods to reconstruct bone defect in clinic at present, so the osteogenic properties and molecular mechanism of bone substitute material have become a hot topic. Minute RNA(mi RNAs are short chain noncoding RNAs, which can affect the expression of osteoblast-associated factors and activate signal transduction in osteoblast-related signal transduction pathway through posttranscriptional regulation of cell differentiation, proliferation, programmed death and other pathophysiological processes. Thus, the dynamic remodeling process of bone tissue was regulated. The relationship between mi RNA and osteoblast specific transcription factor, core binding factor- 伪 1 gene, transforming growth factor- 尾 inducible factor and bone morphogenetic protein signal transduction pathway was studied. The signal transduction pathway of integrative site family and mitogen-activated protein kinase signal transduction pathway in wingless mouse breast tumor virus. The research progress of lipogenic signal transduction pathway, the application of mi RNA and oral materials and mi RNA in bone defect repair is reviewed.
【作者单位】：中山大学光华口腔医学院·附属口腔医院种植科广东省口腔医学重点实验室;
【基金】：国家自然科学基金(81470783)~~
【分类号】：R783

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