慢性牙周炎患者口腔胃幽门螺杆菌感染的相关性分析

发布时间：2018-06-16 02:27

本文选题：幽门螺杆菌 + 慢性牙周病　；参考：《中华医院感染学杂志》2014年05期

【摘要】：目的探讨慢性牙周炎患者口腔胃幽门螺杆菌(Hp)感染的相关性,为提高临床对慢性牙周炎的治疗效果。方法回顾性分析2011年2月-2012年12月35例慢性牙周炎患者,依据特异的尿素酶C和cageA基因设计引物,建立PCR方法,检测牙菌斑和含漱液中的幽门螺杆菌,同时选取同时期的35名牙周健康人员作为对照组,分析两组在检测上的差异性,采用SPSS13.0软件进行统计分析。结果在尿素酶C基因阳性和尿素酶C基因、cageA基因阳性率对照组分别为37.1%、11.4%;观察组分别为68.6%、31.4%,两组比较差异有统计学意义(P0.05);龈下菌斑和龈上菌斑比较差异有统计学意义(P0.05);轻、中、重度牙周炎中的Hp检出阳性率中以轻度的为最低,以上差异均有统计学意义。结论胃幽门螺杆菌可能参与了慢性牙周病的致病过程,两者之间存在一定的相关性。
[Abstract]:Objective to investigate the correlation of Helicobacter pylori (HP) infection in the oral cavity of patients with chronic periodontitis and to improve the therapeutic effect of chronic periodontitis. Methods from February 2011 to December 2012, 35 patients with chronic periodontitis were analyzed retrospectively. Primers were designed according to specific urease C and cageA genes to detect Helicobacter pylori in dental plaque and gargle. At the same time, 35 periodontal health workers in the same period were selected as the control group, and the differences between the two groups were analyzed. SPSS 13.0 software was used for statistical analysis. Results the positive rates of urease C gene and urease C gene cageA gene in the control group were 37.1% and 11.4%, respectively; in the observation group, 68.6% and 31.4%, respectively. The difference between the two groups was statistically significant (P0.05). The difference between subgingival plaque and supragingival plaque was significant (P 0.05). The positive rate of HP in severe periodontitis was the lowest in mild periodontitis. Conclusion Helicobacter pylori may be involved in the pathogenesis of chronic periodontal disease.
【作者单位】：浙江省立同德医院口腔科;
【基金】：浙江省中医药科学研究基金项目(2012ZB009)
【分类号】：R781.42

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