解毒愈溃汤结合西医疗法治疗糜烂型口腔扁平苔藓40例

发布时间：2018-06-22 04:16

本文选题：口腔扁平苔藓 + 糜烂型　；参考：《中国实验方剂学杂志》2015年02期

【摘要】：目的:探讨解毒愈溃汤联合西医常规疗法治疗糜烂型口腔扁平苔藓(OLP)的近期和远期疗效及对血清肿瘤坏死因子α(TNF-α)、白介素-2,4,10(IL-2,4,10)的影响。方法:将80例符合条件的患者随机按就诊前后分为对照组和中西医结合组各40例。对照组采用复方氯己定含漱液,3次/d,连续使用2周;醋酸曲安奈德1 m L+2%利多卡因2 m L,糜烂区黏膜下局部注射,连续使用4周;口服维生素A,C,连续服用12周。中西医结合组在对照组治疗的基础上加服解毒愈溃汤加减治疗,1剂/d,疗程12周。客观指标体征、主观症状和生活质量于治疗前及治疗后4周进行评价;血清TNF-α,IL-2,4,10水平在治疗前、后进行检测。结果:经Ridit分析,中西医结合组临床疗效优于对照组(P0.05);治疗4周后两组客观指标征记分、疼痛评分及生活质量评分均较治疗前下降,中西医结合组下降更为显著(P0.01);治疗后12周,中西医结合组TNF-α,IL-2,IL-4和IL-10水平均低于对照组(P0.01);中西医结合组复发率为22.5%,低于对照组的45.0%(P0.05)。结论:解毒愈溃汤配合西医常规疗法治疗糜烂型口腔扁平苔藓近期能减轻患者的症状、提高患者生活质量,提高临床疗效,远期能降低复发率。其作用可能通过调节T细胞介导的炎性反应来实现的。
[Abstract]:Objective: to investigate the short and long term effects of jiedu Yukui decoction combined with western medicine in the treatment of erosive oral lichen planus (OLP) and its effect on serum tumor necrosis factor 伪 (TNF- 伪) and interleukin-2 (IL-2)-4 + 10 (IL-2 + 4 + 10) in patients with erosive oral lichen planus (OLP). Methods: 80 eligible patients were randomly divided into control group (40 cases) and integrated Chinese and western medicine group (40 cases). The control group was treated with compound chlorhexidine gargle for 3 / d for 2 weeks, triamcinolone acetonide acetate 1 mL / 2% lidocaine 2 mL, submucosal injection in erosive area for 4 weeks, and vitamin A C orally for 12 weeks. The control group was treated with jiedu Yukui decoction for 12 weeks. Objective indexes, subjective symptoms and quality of life were evaluated before and 4 weeks after treatment, and the serum levels of TNF- 伪 and IL-2 + 4 + 10 were detected before and after treatment. Results: by Ridit analysis, the clinical curative effect of the integrated Chinese and western medicine group was better than that of the control group (P0.05), the objective index score, pain score and quality of life score of the two groups were lower than those before treatment after 4 weeks of treatment, especially in the integrated traditional Chinese and western medicine group (P0.01), 12 weeks after treatment, the scores of objective index, pain and quality of life in the two groups were significantly decreased (P0.01). The levels of IL-4 and IL-10 in TNF- 伪 and IL-2 were lower than those in control group (P0.01), and the recurrence rate of TNF- 伪 IL-2IL-4 and IL-10 in integrated TCM group was 22.5g, lower than 45.0% in control group (P0.05). Conclusion: jiedu Yukui decoction combined with routine western medicine treatment of erosive oral lichen planus can alleviate the symptoms of the patients, improve the quality of life of the patients, improve the clinical efficacy, and reduce the recurrence rate in the long term. Its effect may be achieved by regulating T-cell-mediated inflammatory response.
【作者单位】：首都医科大学附属北京世纪坛医院;
【分类号】：R781.5

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