上皮间质转化及TGF-β1在口腔癌中的表达及意义

发布时间：2018-06-29 01:32

本文选题：上皮间质转化 + TGF-β　；参考：《实用口腔医学杂志》2014年02期

【摘要】：通过免疫组化(SP法)技术检测54例口腔癌中E-cadherin、Vimentin及TGF-β1的表达,结果显示E-cadherin、Vimentin及TGF-β1表达阳性率分别为55.6%、33.33%、59.3%,与正常口腔黏膜相比差异有显著性(P0.05);TGF-β1表达不仅与淋巴结转移密切相关,且与Vimentin表达呈显著正相关关系。口腔癌可通过上皮间质转化EMT促进侵袭转移,TGF-β1促进EMT进程。
[Abstract]:The expression of Vimentin and TGF- 尾 1 in 54 cases of oral carcinoma was detected by immunohistochemistry (SP method). The results showed that the positive rates of E-cadherinon vimentin and TGF- 尾 1 were 55.6% and 33.3333% respectively. The expression of TGF- 尾 1 was not only closely related to lymph node metastasis, but also significantly different from that of normal oral mucosa. There was a significant positive correlation between Vimentin expression and Vimentin expression. Oral carcinoma can promote invasion and metastasis by transforming EMT into epithelium. TGF- 尾 1 can promote EMT process.
【作者单位】：滨州医学院病理学教研室;滨州医学院影像学教研室;
【分类号】：R739.85

【参考文献】