米诺环素治疗急性逆行性牙髓炎的临床观察

发布时间：2018-06-30 21:48

本文选题：米诺环素 + 急性逆行性牙髓炎　；参考：《中国药房》2017年08期

【摘要】：目的:观察米诺环素治疗急性逆行性牙髓炎(ARP)的临床疗效、安全性及对患者疼痛症状的影响。方法:选择2015年1-10月青岛农业大学校医院和青岛大学医学院附属医院收治的ARP患者100例(100颗),按随机数字表法分为观察组和对照组,各50例(50颗)。对照组患者给予甲醛甲酚溶液根管封药治疗,观察组患者给予盐酸米诺环素软膏根管封药治疗。两组患者均3 d后复诊,随访5个月后评价疗效;观察治疗前及治疗后3 d疼痛症状评分及白细胞介素-2(IL-2)及肿瘤坏死因子α(TNF-α)水平并记录两组患者不良反应发生情况。结果:观察组患者临床总有效率为98.00%,显著高于对照组的86.00%,差异有统计学意义(P0.05)。治疗前,两组患者叩痛评分、松动度评分、IL-2、TNF-α比较,差异均无统计学意义(P0.05);治疗3 d后,两组患者叩痛评分、松动度评分、IL-2、TNF-α水平均显著降低,且观察组显著低于对照组,差异均有统计学意义(P0.05)。两组患者不良反应总发生率比较,差异无统计学意义(P0.05)。结论:米诺环素治疗ARP疗效显著,能有效改善患者的疼痛症状,且安全性较好。
[Abstract]:Aim: to observe the clinical efficacy, safety and pain symptoms of minocycline in the treatment of acute retrograde pulpitis (ARP). Methods: 100 ARP patients were selected from Qingdao Agricultural University Hospital and affiliated Hospital of Qingdao University Medical College from January to October 2015. They were randomly divided into observation group and control group, 50 cases (50) in each group. The patients in the control group were treated with formaldehyde cresol solution and the patients in the observation group were treated with minocycline hydrochloride ointment. The patients in both groups were followed up for 5 months, and the pain symptom scores, interleukin-2 (IL-2) and tumor necrosis factor- 伪 (TNF- 伪) levels were observed before and 3 days after treatment, and the adverse reactions were recorded. Results: the total clinical effective rate of the observation group was 98.00, which was significantly higher than that of the control group (86.00) (P0.05). Before treatment, there was no significant difference between the two groups in the score of percussion pain, the score of mobility and the score of IL-2TNF- 伪 (P0.05), after 3 days of treatment, the scores of percussion pain and mobility of patients in the two groups decreased significantly, and the level of IL-2TNF- 伪 in the observation group was significantly lower than that in the control group. The difference was statistically significant (P0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P0.05). Conclusion: minocycline is effective in the treatment of ARP.
【作者单位】：青岛农业大学校医院;青岛大学医学院附属医院口腔科;
【分类号】：R781.31

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