GSTM1基因、吸烟及饮酒与亚洲人群口腔癌易感性的Meta分析

发布时间：2018-07-03 02:46

本文选题：谷胱甘肽-S-转移酶M + 基因多态性　；参考：《实用口腔医学杂志》2014年04期

【摘要】：目的:采用循证医学Meta分析方法评价谷胱甘肽-S-转移酶M1(GSTM1)基因多态性、吸烟及饮酒与亚洲人群口腔癌易感性的关联。方法:计算机检索PubMed、CBM、万方、维普、CNKI等中英文数据库,检索范围从建库至2013-07-30全面收集相关文献数据计算优势比(OR)及95%置信区间(95%CI)以评价关联性。结果:纳入27项病例对照研究,结果:GSTM1缺失基因型与亚洲人群口腔癌发病风险显著相关(OR=1.31,95%CI:1.18~1.45,P0.001),在南亚人群中尤为显著(OR=1.35,95%CI:1.20~1.52,P0.001);吸烟和饮酒与口腔癌易感性之间的关联在东亚人群中显著(吸烟:OR=1.70,95%CI:1.36~2.13,P0.001;饮酒:OR=1.54,95%CI:1.24~1.90,P0.001),在南亚人群中不显著。结论:GSTM1缺失基因型与亚洲人群口腔癌易感性显著关联,吸烟和饮酒与口腔癌易感性在东亚人群中显著关联。
[Abstract]:Objective: to evaluate the association of glutathione -Stransferase M1 (GSTM1) gene polymorphism, smoking and alcohol consumption with oral cancer susceptibility in Asian population by evidence-based medicine meta-analysis. Methods: a computer-based database was searched for CBM, Wanfang, CNKI and so on. The relevant literature data were collected from the database construction to 2013-07-30. The odds ratio (OR) and 95% confidence interval (95 CI) were collected to evaluate the correlation. Results: in 27 case-control studies, Results there was a significant correlation between the loss of the 1: GSTM1 genotype and the risk of oral cancer in Asian population (OR1.3195), especially in South Asia (OR1.355.95 CI: 1.201.20: 1.52P0.001); the association between smoking, drinking and oral cancer susceptibility was significant in East Asian population (smoking: 1.70% 95CIw 1.362.13P0.001; in South Asia), the relationship between smoking and drinking was 1.241.90 P0.001; and in South Asia, the relationship between smoking and drinking was significant (OR 1.70: 95 CI: 1.362.13P0.001; in South Asia), the relationship between smoking and alcohol consumption was 1.241.90 P0.001; in South Asia, the relationship between smoking and drinking was 1.241.90 P0.001; in South Asia, the relationship between smoking, drinking and oral cancer was significant. The subpopulation was not significant. Conclusion there is a significant association between the deletion of GSTM1 gene and the susceptibility to oral cancer in Asian population, and the association between smoking and alcohol consumption and oral cancer susceptibility in East Asian population.
【作者单位】：上海浦东新区浦南医院口腔科;上海交通大学医学院附属第九人民医院口腔医学院口腔颌面外科·上海口腔重点实验室;
【分类号】：R739.8

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