慢性牙周炎基础治疗后龈沟液中基质金属蛋白酶-8含量的变化

发布时间：2018-07-04 17:22

本文选题：慢性牙周炎 + 龈沟液　；参考：《现代预防医学》2014年04期

【摘要】：目的探讨龈沟液中基质金属蛋白酶-8(MMP-8)含量的变化与慢性牙周炎病情的关系。方法选取56例慢性牙周炎为研究对象及合适位点,在牙周基础治疗前后分别测定患牙牙周临床指标及龈沟液MMP--8含量,并分析其与牙周临床指标的相关性。结果慢性牙周炎基础治疗后PD、GI均有改善,伴随着炎症的减轻与控制,MMP-8的含量也明显降低(P0.01);治疗前龈沟液中MMP-8含量与PD之间呈显著性正相关(P0.05),与AL、GI、ABL之间均呈非常显著性正相关(P0.01);治疗后龈沟液中MMP-8含量与PD、AL、ABL之间均呈显著性正相关(P0.05),与GI之间呈非常显著性相关(P0.01)。结论 MMP-8参与了牙周组织破坏的病理过程,其含量的变化与牙周临床指标的变化一致,检测MMP-8含量有助于牙周炎的诊断,可以判断牙周炎的严重程度、进展及恢复情况,也可以作为监测牙周炎治疗效果的一种手段。
[Abstract]:Objective to investigate the relationship between the changes of matrix metalloproteinase-8 (MMP-8) in gingival crevicular fluid and chronic periodontitis. Methods 56 cases of chronic periodontitis were selected as the study object and suitable site. The clinical indexes of periodontal and the content of MMP-8 in gingival crevicular fluid were measured before and after basic periodontal treatment, and the correlation between MMP-8 and periodontal clinical indexes was analyzed. Results PDGI was improved after basic treatment of chronic periodontitis. The content of MMP-8 in gingival crevicular fluid was positively correlated with PD before treatment (P0.05) and was positively correlated with ALGIABL (P0.01), and the content of MMP-8 in gingival crevicular fluid was positively correlated with PDALABL after treatment (P0.01). There was a significant positive correlation between the two groups (P0.05) and a very significant correlation with GI (P0.01). Conclusion MMP-8 is involved in the pathological process of periodontal tissue destruction, and the change of MMP-8 content is consistent with the change of periodontal clinical indexes. The detection of MMP-8 content is helpful to the diagnosis of periodontitis and can be used to judge the severity, progress and recovery of periodontitis. It can also be used as a means to monitor the therapeutic effect of periodontitis.
【作者单位】：漯河医学高等专科学校第三附属医院;漯河市中心医院;
【分类号】：R781.42

【参考文献】