HIF-1α-Glut1信号轴在口腔鳞癌中的表达及意义

发布时间：2018-07-07 15:45

  本文选题：口腔鳞癌 + 缺氧诱导因子-1α　； 参考：《南京大学》2016年硕士论文

【摘要】：目的探究HIF-1α, Glut1在口腔鳞癌中的表达特征及其与患者预后的关系。方法采用免疫组化sp法检测90例手术切除的原发性口腔癌患者肿瘤组织中HIF-1α, Glut1, Ki67的表达,并采用SPSS, Graphpad统计学软件。将实验结果与患者临床病理学参数及生存天数进行统计学分析。结果HIF-1α, Glut1蛋白在选取的口腔鳞癌组织中正常表达,HIF-1α与Glutl在选取的口腔鳞癌组织中的阳性表达率分别为65.6%(59/90)与45.7%(42/90)。HIF-1α的阳性表达与患者的术后生存时间有负相关的趋势,但没有统计学上的显著差异(0.05P0.10), Glut1的阳性表达与患者的术后生存天数无明显相关。(P0.05) HIF-1α与Glutl的双阳性与患者的术后生存时间之间具有显著的负相关(P0.05)。 HIF-1α. Glut1以及它们的双阳性与Ki67的表达之间均无显著关系。HIF-1α、Glut1的表达与患者的年龄,性别,是否吸烟,组织学分级,T分期,发病部位均无显著的相关性。结论HIF-1α与Glut1的双阳性与口腔鳞癌患者的不良预后具有显著的相关性,HIF-1α与Glut的双阳性能作为预测口腔鳞癌患者不良预后的指标。
[Abstract]:Objective to investigate the expression of HIF-1 伪 and Glut1 in oral squamous cell carcinoma (OSCC) and the relationship between HIF-1 伪 and prognosis. Methods the expressions of HIF-1 伪, Glut1 and Ki67 in 90 patients with primary oral cancer were detected by immunohistochemical sp method. SPSS and Graphpad software were used to analyze the expression of HIF-1 伪, Glut1 and Ki67. The experimental results were statistically analyzed with the clinicopathological parameters and survival days of the patients. Results the positive expression rates of HIF-1 伪 and Glutl in selected oral squamous cell carcinoma tissues were 65.6% (59 / 90) and 45.7% (42 / 90). But there was no statistically significant difference (0.05P0.10), the positive expression of Glut1 had no significant correlation with postoperative survival days. (P0.05) there was a significant negative correlation between HIF-1 伪 and Glutl double positive expression and postoperative survival time (P0.05). HIF-1 伪. There was no significant correlation between Glut1, their double positive and Ki67 expression. There was no significant correlation between HIF-1 伪 and Glut1 expression and age, sex, smoking, histological grade and T stage. Conclusion the double positive expression of HIF-1 伪 and Glut1 is significantly correlated with the poor prognosis of patients with oral squamous cell carcinoma (OSCC). HIF-1 伪 and Glut's double positive properties can be used as an index to predict the poor prognosis of oral squamous cell carcinoma (OSCC).
【学位授予单位】：南京大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R739.85
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本文编号：2105440